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Article: Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure

TitleCirculating adipocyte fatty acid-binding protein levels are independently associated with heart failure
Authors
Issue Date2013
PublisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/
Citation
Clinical Science, 2013, v. 124 n. 2, p. 115-122 How to Cite?
AbstractA-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins in adipocytes, plays a key role in obesity-related insulin resistance, inflammation and atherosclerosis in animals. In the present study, we sought to investigate the association of A-FABP with HF (heart failure) in Chinese subjects. Serum A-FABP levels were measured in 252 HF patients and 261 age-, gender- and BMI (body mass index)-matched non-HF subjects. Echocardiography was performed on each patient. The severity of HF was determined by the NYHA (New York Heart Association) classification system. After adjustments for age, gender and BMI, serum A-FABP concentrations in patients with HF were significantly higher than in non-HF patients [11.17 (6.63-19.93) ng/ml compared with 5.67 (3.20-8.87) ng/ml; P<0.001] and significantly progressed with the NYHA class (P<0.001). In addition, NT-proBNP (N-terminal pro-brain natriuretic peptide) was independently and positively correlated with A-FABP (standardized beta=0.340, P<0.001) after adjusting for confounding factors. Each echocardiographic parameter, especially LVEF (left ventricular ejection fraction), was independently associated with A-FABP (all P<0.05). Multivariate logistic regression analysis demonstrated that A-FABP concentration was an independent risk factor for HF [odds ratio, 6.93 (95% confidence interval, 2.49-19.30); P<0.001]. Our results demonstrate that A-FABP is closely associated with HF, and raise the possibility that increased A-FABP may be causally related to the pathogenesis of heart dysfunction in humans.
Persistent Identifierhttp://hdl.handle.net/10722/197233
ISSN
2015 Impact Factor: 4.996
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Men_US
dc.contributor.authorZhou, Men_US
dc.contributor.authorBao, Yen_US
dc.contributor.authorXu, Zen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorZhu, Wen_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorJia, Wen_US
dc.date.accessioned2014-05-23T02:27:37Z-
dc.date.available2014-05-23T02:27:37Z-
dc.date.issued2013en_US
dc.identifier.citationClinical Science, 2013, v. 124 n. 2, p. 115-122en_US
dc.identifier.issn0143-5221en_US
dc.identifier.urihttp://hdl.handle.net/10722/197233-
dc.description.abstractA-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins in adipocytes, plays a key role in obesity-related insulin resistance, inflammation and atherosclerosis in animals. In the present study, we sought to investigate the association of A-FABP with HF (heart failure) in Chinese subjects. Serum A-FABP levels were measured in 252 HF patients and 261 age-, gender- and BMI (body mass index)-matched non-HF subjects. Echocardiography was performed on each patient. The severity of HF was determined by the NYHA (New York Heart Association) classification system. After adjustments for age, gender and BMI, serum A-FABP concentrations in patients with HF were significantly higher than in non-HF patients [11.17 (6.63-19.93) ng/ml compared with 5.67 (3.20-8.87) ng/ml; P<0.001] and significantly progressed with the NYHA class (P<0.001). In addition, NT-proBNP (N-terminal pro-brain natriuretic peptide) was independently and positively correlated with A-FABP (standardized beta=0.340, P<0.001) after adjusting for confounding factors. Each echocardiographic parameter, especially LVEF (left ventricular ejection fraction), was independently associated with A-FABP (all P<0.05). Multivariate logistic regression analysis demonstrated that A-FABP concentration was an independent risk factor for HF [odds ratio, 6.93 (95% confidence interval, 2.49-19.30); P<0.001]. Our results demonstrate that A-FABP is closely associated with HF, and raise the possibility that increased A-FABP may be causally related to the pathogenesis of heart dysfunction in humans.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/en_US
dc.relation.ispartofClinical Scienceen_US
dc.rightsThe final version of record is available at [Journal URL].en_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAnthropometryen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshFatty Acid-Binding Proteins - blooden_US
dc.subject.meshHeart Failure - blooden_US
dc.titleCirculating adipocyte fatty acid-binding protein levels are independently associated with heart failureen_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: hjzhang@hkucc.hku.hken_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.doi10.1042/CS20120004en_US
dc.identifier.pmid23013043en_US
dc.identifier.hkuros221753en_US
dc.identifier.volume124en_US
dc.identifier.issue2en_US
dc.identifier.spage115en_US
dc.identifier.epage122en_US
dc.identifier.isiWOS:000313406100011-
dc.publisher.placeUnited Kingdomen_US

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