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Article: A novel study design to investigate the early-life origins of asthma in children (SAGE study).

TitleA novel study design to investigate the early-life origins of asthma in children (SAGE study).
Authors
Issue Date2009
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ALL
Citation
Allergy: European journal of allergy and immunology, 2009, v. 64 n. 8, p. 1185-1193 How to Cite?
AbstractThis is a description of the Study of Asthma, Genes and the Environment (SAGE), a novel birth cohort created from provincial healthcare administrative records. It is a general population-based cohort, composed of children at high and low risk for asthma, living in urban and rural environments in Manitoba, Canada. The SAGE study captures the complete longitudinal healthcare records of children born in 1995 and contains detailed information on early-life exposures, such as antibiotic utilization and immunization, in relationship to the development of asthma. Nested within the birth cohort is a case-control study, which was created to collect information on home environmental exposures from detailed surveys and home dust sampling, to confirm asthma status in children and use this data to validate healthcare database measures of asthma, to determine differences in immune system responsiveness to innate and adaptive immune stimuli in asthma, to genotype children for genes likely associated with the development of asthma and to study the epigenetic regulation of pre-established protective vs allergic immune responses. The SAGE study is a multidisciplinary collaboration of researchers from pediatric allergy, population health, immunology, and genetic and environmental epidemiology. As such, it serves as a fertile, interdisciplinary training ground for graduate students, and postdoctoral and clinician fellows.
Persistent Identifierhttp://hdl.handle.net/10722/197222
ISSN
2015 Impact Factor: 6.335
2015 SCImago Journal Rankings: 3.048
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKozyrskyj, ALen_US
dc.contributor.authorHayGlass, KTen_US
dc.contributor.authorPare, PDen_US
dc.contributor.authorChan, MMWen_US
dc.contributor.authorBecker, ABen_US
dc.date.accessioned2014-05-23T02:27:31Z-
dc.date.available2014-05-23T02:27:31Z-
dc.date.issued2009en_US
dc.identifier.citationAllergy: European journal of allergy and immunology, 2009, v. 64 n. 8, p. 1185-1193en_US
dc.identifier.issn0105-4538-
dc.identifier.urihttp://hdl.handle.net/10722/197222-
dc.description.abstractThis is a description of the Study of Asthma, Genes and the Environment (SAGE), a novel birth cohort created from provincial healthcare administrative records. It is a general population-based cohort, composed of children at high and low risk for asthma, living in urban and rural environments in Manitoba, Canada. The SAGE study captures the complete longitudinal healthcare records of children born in 1995 and contains detailed information on early-life exposures, such as antibiotic utilization and immunization, in relationship to the development of asthma. Nested within the birth cohort is a case-control study, which was created to collect information on home environmental exposures from detailed surveys and home dust sampling, to confirm asthma status in children and use this data to validate healthcare database measures of asthma, to determine differences in immune system responsiveness to innate and adaptive immune stimuli in asthma, to genotype children for genes likely associated with the development of asthma and to study the epigenetic regulation of pre-established protective vs allergic immune responses. The SAGE study is a multidisciplinary collaboration of researchers from pediatric allergy, population health, immunology, and genetic and environmental epidemiology. As such, it serves as a fertile, interdisciplinary training ground for graduate students, and postdoctoral and clinician fellows.-
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ALL-
dc.relation.ispartofAllergy: European journal of allergy and immunologyen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshAsthma - diagnosis - epidemiology-
dc.subject.meshManitoba - epidemiology-
dc.subject.meshRecords as Topic-
dc.subject.meshResearch Design-
dc.subject.meshRisk Factors-
dc.titleA novel study design to investigate the early-life origins of asthma in children (SAGE study).en_US
dc.typeArticleen_US
dc.identifier.emailChan, MMW: mmwchan@hku.hken_US
dc.identifier.doi10.1111/j.1398-9995.2009.02033.x-
dc.identifier.pmid19416140-
dc.identifier.hkuros162556en_US
dc.identifier.volume64en_US
dc.identifier.issue8en_US
dc.identifier.spage1185en_US
dc.identifier.epage1193en_US
dc.identifier.isiWOS:000267830700012-
dc.publisher.placeDenmark-

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