File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness.

TitleA thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness.
Authors
KeywordsAirway hyperresponsiveness
Thymic stromal lymphopoietin
Asthma genetics
Atopy
Polymorphisms
Issue Date2009
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jaci
Citation
Journal of Allergy and Clinical Immunology, 2009, v. 124 n. 2, p. 222-229 How to Cite?
AbstractBackground The epithelial cell–derived protein thymic stromal lymphopoietin stimulates dendritic and mast cells to promote proallergic TH2 responses. Studies of transgenic expression of thymic stromal lymphopoietin and its receptor knockout mice have emphasized its critical role in the development of allergic inflammation. Association of genetic variation in thymic stromal lymphopoietin with IgE levels has been reported for human subjects. Objective The aim of this study was to evaluate the relationship between variants of thymic stromal lymphopoietin and asthma and related phenotypes. Methods We selected 6 single nucleotide polymorphisms in thymic stromal lymphopoietin and genotyped 5565 individuals from 4 independent asthma studies and tested for association with asthma, atopy, atopic asthma, and airway hyperresponsiveness by using a general allelic likelihood ratio test. P values were corrected for the effective number of independent single nucleotide polymorphisms and phenotypes. Results The A allele of rs1837253, which is 5.7 kb upstream of the transcription start site of the gene, was associated with protection from asthma, atopic asthma, and airway hyperresponsiveness, with the odds ratios and corrected P values for each being 0.79 and 0.0058; 0.75 and 0.0074; and 0.76 and 0.0094, respectively. Associations between thymic stromal lymphopoietin and asthma-related phenotypes were the most statistically significant observations in our study, which has to date examined 98 candidate genes. Full results are available online at http://genapha.icapture.ubc.ca/. Conclusions A genetic variant in the region of the thymic stromal lymphopoietin gene is associated with the phenotypes of asthma and airway hyperresponsiveness.
Persistent Identifierhttp://hdl.handle.net/10722/197221
ISSN
2015 Impact Factor: 12.485
2015 SCImago Journal Rankings: 5.513
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHe, JQen_US
dc.contributor.authorHallstrand, TSen_US
dc.contributor.authorKnight, Den_US
dc.contributor.authorChan, MMWen_US
dc.contributor.authorSandford, Aen_US
dc.contributor.authorTripp, Ben_US
dc.contributor.authorZamar, Den_US
dc.contributor.authorBosse, Yen_US
dc.contributor.authorKozyrskyj, ALen_US
dc.contributor.authorJames, Aen_US
dc.contributor.authorLaprise, Cen_US
dc.contributor.authorDaley, Den_US
dc.date.accessioned2014-05-23T02:27:31Z-
dc.date.available2014-05-23T02:27:31Z-
dc.date.issued2009en_US
dc.identifier.citationJournal of Allergy and Clinical Immunology, 2009, v. 124 n. 2, p. 222-229en_US
dc.identifier.issn0091-6749-
dc.identifier.urihttp://hdl.handle.net/10722/197221-
dc.description.abstractBackground The epithelial cell–derived protein thymic stromal lymphopoietin stimulates dendritic and mast cells to promote proallergic TH2 responses. Studies of transgenic expression of thymic stromal lymphopoietin and its receptor knockout mice have emphasized its critical role in the development of allergic inflammation. Association of genetic variation in thymic stromal lymphopoietin with IgE levels has been reported for human subjects. Objective The aim of this study was to evaluate the relationship between variants of thymic stromal lymphopoietin and asthma and related phenotypes. Methods We selected 6 single nucleotide polymorphisms in thymic stromal lymphopoietin and genotyped 5565 individuals from 4 independent asthma studies and tested for association with asthma, atopy, atopic asthma, and airway hyperresponsiveness by using a general allelic likelihood ratio test. P values were corrected for the effective number of independent single nucleotide polymorphisms and phenotypes. Results The A allele of rs1837253, which is 5.7 kb upstream of the transcription start site of the gene, was associated with protection from asthma, atopic asthma, and airway hyperresponsiveness, with the odds ratios and corrected P values for each being 0.79 and 0.0058; 0.75 and 0.0074; and 0.76 and 0.0094, respectively. Associations between thymic stromal lymphopoietin and asthma-related phenotypes were the most statistically significant observations in our study, which has to date examined 98 candidate genes. Full results are available online at http://genapha.icapture.ubc.ca/. Conclusions A genetic variant in the region of the thymic stromal lymphopoietin gene is associated with the phenotypes of asthma and airway hyperresponsiveness.-
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jaci-
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_US
dc.subjectAirway hyperresponsiveness-
dc.subjectThymic stromal lymphopoietin-
dc.subjectAsthma genetics-
dc.subjectAtopy-
dc.subjectPolymorphisms-
dc.titleA thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness.en_US
dc.typeArticleen_US
dc.identifier.emailChan, MMW: mmwchan@hku.hken_US
dc.identifier.doi10.1016/j.jaci.2009.04.018-
dc.identifier.pmid19539984-
dc.identifier.scopuseid_2-s2.0-67849132402-
dc.identifier.hkuros162555en_US
dc.identifier.volume124-
dc.identifier.issue2-
dc.identifier.spage222-
dc.identifier.epage229-
dc.identifier.isiWOS:000268860400007-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats