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Article: Structural plasticity of dendritic spines: The underlying mechanisms and its dysregulation in brain disorders

TitleStructural plasticity of dendritic spines: The underlying mechanisms and its dysregulation in brain disorders
Authors
Issue Date2013
Citation
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2013, v. 1832 n. 12, p. 2257-2263 How to Cite?
AbstractDendritic spines are specialized structures on neuronal processes where the majority of excitatory synapses are localized. Spines are highly dynamic, and their stabilization and morphology are influenced by synaptic activity. This extrinsic regulation of spine morphogenesis underlies experience-dependent brain development and information storage within the brain circuitry. In this review, we summarize recent findings that demonstrate the phenomenon of activity-dependent structural plasticity and the molecular mechanisms by which synaptic activity sculpt neuronal connections. Impaired structural plasticity is associated with perturbed brain function in neurodevelopmental disorders such as autism. Information from the mechanistic studies therefore provides important insights into the design of therapeutic strategies for these brain disorders. © 2013.
Persistent Identifierhttp://hdl.handle.net/10722/196724
ISSN
2015 Impact Factor: 5.158
2015 SCImago Journal Rankings: 2.718
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, K-O-
dc.contributor.authorIp, NY-
dc.date.accessioned2014-04-24T02:10:36Z-
dc.date.available2014-04-24T02:10:36Z-
dc.date.issued2013-
dc.identifier.citationBiochimica et Biophysica Acta - Molecular Basis of Disease, 2013, v. 1832 n. 12, p. 2257-2263-
dc.identifier.issn0925-4439-
dc.identifier.urihttp://hdl.handle.net/10722/196724-
dc.description.abstractDendritic spines are specialized structures on neuronal processes where the majority of excitatory synapses are localized. Spines are highly dynamic, and their stabilization and morphology are influenced by synaptic activity. This extrinsic regulation of spine morphogenesis underlies experience-dependent brain development and information storage within the brain circuitry. In this review, we summarize recent findings that demonstrate the phenomenon of activity-dependent structural plasticity and the molecular mechanisms by which synaptic activity sculpt neuronal connections. Impaired structural plasticity is associated with perturbed brain function in neurodevelopmental disorders such as autism. Information from the mechanistic studies therefore provides important insights into the design of therapeutic strategies for these brain disorders. © 2013.-
dc.languageeng-
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Basis of Disease-
dc.titleStructural plasticity of dendritic spines: The underlying mechanisms and its dysregulation in brain disorders-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbadis.2013.08.012-
dc.identifier.pmid24012719-
dc.identifier.scopuseid_2-s2.0-84884511387-
dc.identifier.hkuros240815-
dc.identifier.volume1832-
dc.identifier.issue12-
dc.identifier.spage2257-
dc.identifier.epage2263-
dc.identifier.isiWOS:000327567600036-

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