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Article: Influence of IL-6 haplotypes on clinical and inflammatory response in aggressive periodontitis

TitleInfluence of IL-6 haplotypes on clinical and inflammatory response in aggressive periodontitis
Authors
Issue Date2013
Citation
Clinical Oral Investigations, 2013, v. 17 n. 4, p. 1235-1242 How to Cite?
AbstractObjectives: The aim of this study was to investigate the inflammatory response in aggressive periodontitis (AgP) patients after periodontal therapy and associate these changes to subjects' interleukin-6 (IL-6) genetic variants. Materials and methods: Twelve non-smoking UK Caucasian patients with AgP were selected based on their IL6 haplotypes (six haplotype positive and six haplotype negative based on polymorphisms rs 2069827 and rs 2069825) and underwent full mouth non-surgical periodontal therapy, followed by open flap surgery. Gingival crevicular fluid (GCF) and peripheral blood samples were taken at baseline and at six different time points after treatment. Gingival biopsy samples were harvested during surgery and underwent immunohistochemical analysis for identification of IL-6. Results: An overall improvement in clinical periodontal parameters was observed following periodontal therapy. Haplotype status was associated with clinical presentation, Aggregatibacter actinomycetemcomitans counts in subgingival plaque samples, white cell count, neutrophils, red cell count and haemoglobin. GCF IL-6 concentrations increased dramatically 1 day after surgery and IL-6 haplotype-positive subjects exhibited a higher magnitude in this increase. Conclusions: IL6 haplotypes may have an effect on clinical presentation and magnitude and kinetics of local and systemic inflammatory responses following non-surgical and surgical periodontal therapy in aggressive periodontitis. Clinical relevance: Detecting IL-6 haplotype-positive periodontitis patients might become helpful in identifying subjects prone to excessive inflammatory response and increased periodontal breakdown. © 2012 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/196721
ISSN
2015 Impact Factor: 2.207
2015 SCImago Journal Rankings: 0.752
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNibali, L-
dc.contributor.authorPelekos, G-
dc.contributor.authorD'Aiuto, F-
dc.contributor.authorChaudhary, N-
dc.contributor.authorHabeeb, R-
dc.contributor.authorReady, D-
dc.contributor.authorParkar, M-
dc.contributor.authorDonos, N-
dc.date.accessioned2014-04-24T02:10:36Z-
dc.date.available2014-04-24T02:10:36Z-
dc.date.issued2013-
dc.identifier.citationClinical Oral Investigations, 2013, v. 17 n. 4, p. 1235-1242-
dc.identifier.issn1432-6981-
dc.identifier.urihttp://hdl.handle.net/10722/196721-
dc.description.abstractObjectives: The aim of this study was to investigate the inflammatory response in aggressive periodontitis (AgP) patients after periodontal therapy and associate these changes to subjects' interleukin-6 (IL-6) genetic variants. Materials and methods: Twelve non-smoking UK Caucasian patients with AgP were selected based on their IL6 haplotypes (six haplotype positive and six haplotype negative based on polymorphisms rs 2069827 and rs 2069825) and underwent full mouth non-surgical periodontal therapy, followed by open flap surgery. Gingival crevicular fluid (GCF) and peripheral blood samples were taken at baseline and at six different time points after treatment. Gingival biopsy samples were harvested during surgery and underwent immunohistochemical analysis for identification of IL-6. Results: An overall improvement in clinical periodontal parameters was observed following periodontal therapy. Haplotype status was associated with clinical presentation, Aggregatibacter actinomycetemcomitans counts in subgingival plaque samples, white cell count, neutrophils, red cell count and haemoglobin. GCF IL-6 concentrations increased dramatically 1 day after surgery and IL-6 haplotype-positive subjects exhibited a higher magnitude in this increase. Conclusions: IL6 haplotypes may have an effect on clinical presentation and magnitude and kinetics of local and systemic inflammatory responses following non-surgical and surgical periodontal therapy in aggressive periodontitis. Clinical relevance: Detecting IL-6 haplotype-positive periodontitis patients might become helpful in identifying subjects prone to excessive inflammatory response and increased periodontal breakdown. © 2012 Springer-Verlag.-
dc.languageeng-
dc.relation.ispartofClinical Oral Investigations-
dc.titleInfluence of IL-6 haplotypes on clinical and inflammatory response in aggressive periodontitis-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00784-012-0804-3-
dc.identifier.pmid22918663-
dc.identifier.scopuseid_2-s2.0-84876454185-
dc.identifier.volume17-
dc.identifier.issue4-
dc.identifier.spage1235-
dc.identifier.epage1242-
dc.identifier.isiWOS:000317866800014-

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