File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Tyk2/STAT3 signaling mediates β-amyloid-induced neuronal cell death: Implications in alzheimer's disease

TitleTyk2/STAT3 signaling mediates β-amyloid-induced neuronal cell death: Implications in alzheimer's disease
Authors
Issue Date2010
Citation
Journal of Neuroscience, 2010, v. 30 n. 20, p. 6873-6881 How to Cite?
AbstractOne of the pathological hallmarks of Alzheimer's disease (AD) is deposition of extracellular amyloid-β(Aβ) peptide, which is generated from the cleavage of amyloid precursor protein (APP). Accumulation of Aβ is thought to associate with the progressive neuronal death observed in AD. However, the precise signaling mechanisms underlying the action of Aβ in AD pathophysiology are not completely understood. Here, we report the involvement of the transcription factor signal transducer and activator of transcription 3 (STAT3) in mediating Aβ-induced neuronal death. We find that tyrosine phosphorylation of STAT3 is elevated in the cortex and hippocampus of APP/PS1 transgenic mice. Treatment of cultured rat neurons with Aβ or intrahippocampal injection of mice with Aβ both induces tyrosine phosphorylation of STAT3 in neurons. Importantly, reduction of either the expression or activation of STAT3 markedly attenuates Aβ-induced neuronal apoptosis, suggesting that STAT3 activation contributes to neuronal death after Aβ exposure. We further identify Tyk2 as the tyrosine kinase that acts upstream of STAT3, as Aβ-induced activation of STAT3 and caspase-3-dependent neuronal death can be inhibited in tyk2-/- neurons. Finally, increased tyrosine phosphorylation of STAT3 is also observed in postmortem brains of AD patients. Our observations collectively reveal a novel role of STAT3 in Aβ-induced neuronal death and suggest the potential involvement of Tyk2/STAT3 signaling in AD pathophysiology. Copyright © 2010 the authors.
Persistent Identifierhttp://hdl.handle.net/10722/196716
ISSN
2015 Impact Factor: 5.924
2015 SCImago Journal Rankings: 5.105
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, J-
dc.contributor.authorFu, AKY-
dc.contributor.authorIp, FCF-
dc.contributor.authorNg, H-K-
dc.contributor.authorHugon, J-
dc.contributor.authorPage, G-
dc.contributor.authorWang, JH-
dc.contributor.authorLai, K-O-
dc.contributor.authorWu, Z-
dc.contributor.authorIp, NY-
dc.date.accessioned2014-04-24T02:10:35Z-
dc.date.available2014-04-24T02:10:35Z-
dc.date.issued2010-
dc.identifier.citationJournal of Neuroscience, 2010, v. 30 n. 20, p. 6873-6881-
dc.identifier.issn0270-6474-
dc.identifier.urihttp://hdl.handle.net/10722/196716-
dc.description.abstractOne of the pathological hallmarks of Alzheimer's disease (AD) is deposition of extracellular amyloid-β(Aβ) peptide, which is generated from the cleavage of amyloid precursor protein (APP). Accumulation of Aβ is thought to associate with the progressive neuronal death observed in AD. However, the precise signaling mechanisms underlying the action of Aβ in AD pathophysiology are not completely understood. Here, we report the involvement of the transcription factor signal transducer and activator of transcription 3 (STAT3) in mediating Aβ-induced neuronal death. We find that tyrosine phosphorylation of STAT3 is elevated in the cortex and hippocampus of APP/PS1 transgenic mice. Treatment of cultured rat neurons with Aβ or intrahippocampal injection of mice with Aβ both induces tyrosine phosphorylation of STAT3 in neurons. Importantly, reduction of either the expression or activation of STAT3 markedly attenuates Aβ-induced neuronal apoptosis, suggesting that STAT3 activation contributes to neuronal death after Aβ exposure. We further identify Tyk2 as the tyrosine kinase that acts upstream of STAT3, as Aβ-induced activation of STAT3 and caspase-3-dependent neuronal death can be inhibited in tyk2-/- neurons. Finally, increased tyrosine phosphorylation of STAT3 is also observed in postmortem brains of AD patients. Our observations collectively reveal a novel role of STAT3 in Aβ-induced neuronal death and suggest the potential involvement of Tyk2/STAT3 signaling in AD pathophysiology. Copyright © 2010 the authors.-
dc.languageeng-
dc.relation.ispartofJournal of Neuroscience-
dc.titleTyk2/STAT3 signaling mediates β-amyloid-induced neuronal cell death: Implications in alzheimer's disease-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1523/JNEUROSCI.0519-10.2010-
dc.identifier.pmid20484629-
dc.identifier.scopuseid_2-s2.0-77952604395-
dc.identifier.volume30-
dc.identifier.issue20-
dc.identifier.spage6873-
dc.identifier.epage6881-
dc.identifier.isiWOS:000277844700008-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats