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Article: Postsynaptic signaling of new players at the neuromuscular junction

TitlePostsynaptic signaling of new players at the neuromuscular junction
Authors
Issue Date2003
Citation
Journal of Neurocytology, 2003, v. 32 n. 5-8, p. 727-741 How to Cite?
AbstractThe neuromuscular junction (NMJ) represents the most well studied synapse and is widely regarded as structurally and functionally less complicated than neuronal synapses in the brain. Recent studies, however, have identified the localization and function of new signaling molecules at the NMJ. Surprisingly, many synaptic proteins previously identified in the brain are indeed also concentrated on the postsynaptic muscle side of the NMJ. These include the serine/threonine kinase Cdk5, the neurotrophin receptor TrkB, Eph receptors and ephrins, NMDA receptors and nitric oxide synthase, various PDZ-domain scaffold proteins, and β-amyloid precursor protein. These observations indicate that the molecular composition of NMJ is much more intricate than we originally thought. The potential significance of these new signaling molecules at the NMJ will be discussed.
Persistent Identifierhttp://hdl.handle.net/10722/196669
ISSN
2007 Impact Factor: 1.935
2009 SCImago Journal Rankings: 0.911
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, K-O-
dc.contributor.authorIp, NY-
dc.date.accessioned2014-04-24T02:10:32Z-
dc.date.available2014-04-24T02:10:32Z-
dc.date.issued2003-
dc.identifier.citationJournal of Neurocytology, 2003, v. 32 n. 5-8, p. 727-741-
dc.identifier.issn0300-4864-
dc.identifier.urihttp://hdl.handle.net/10722/196669-
dc.description.abstractThe neuromuscular junction (NMJ) represents the most well studied synapse and is widely regarded as structurally and functionally less complicated than neuronal synapses in the brain. Recent studies, however, have identified the localization and function of new signaling molecules at the NMJ. Surprisingly, many synaptic proteins previously identified in the brain are indeed also concentrated on the postsynaptic muscle side of the NMJ. These include the serine/threonine kinase Cdk5, the neurotrophin receptor TrkB, Eph receptors and ephrins, NMDA receptors and nitric oxide synthase, various PDZ-domain scaffold proteins, and β-amyloid precursor protein. These observations indicate that the molecular composition of NMJ is much more intricate than we originally thought. The potential significance of these new signaling molecules at the NMJ will be discussed.-
dc.languageeng-
dc.relation.ispartofJournal of Neurocytology-
dc.titlePostsynaptic signaling of new players at the neuromuscular junction-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/B:NEUR.0000020620.62318.01-
dc.identifier.pmid15034264-
dc.identifier.scopuseid_2-s2.0-3042536719-
dc.identifier.volume32-
dc.identifier.issue5-8-
dc.identifier.spage727-
dc.identifier.epage741-
dc.identifier.isiWOS:000220340400022-

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