File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Beating heart revascularization with or without cardiopulmonary bypass: Evaluation of inflammatory response in a prospective randomized study

TitleBeating heart revascularization with or without cardiopulmonary bypass: Evaluation of inflammatory response in a prospective randomized study
Authors
Issue Date2004
Citation
Journal of Thoracic and Cardiovascular Surgery, 2004, v. 127 n. 6, p. 1624-1631 How to Cite?
AbstractObjective: On-pump beating heart coronary artery surgery provides the opportunity to examine the isolated effect of cardiopulmonary bypass. This prospective randomized study compares the early clinical outcomes and inflammatory response of patients undergoing elective on-pump and off-pump beating heart coronary artery bypass grafting. Method and Patients: Thirty-seven consecutive patients undergoing elective coronary artery bypass grafting were recruited from a pool of 73 patients, with 19 patients randomized to on-pump beating heart surgery and 18 patients to off-pump coronary bypass surgery. Intraoperative events and postoperative outcomes were recorded. Plasma levels of interleukin-6, interleukin-8, and interleukin-10, tumor necrosis factor-alpha, and vascular cell adhesion molecule-1 were measured before the operation, intraoperatively, after the operation, and 4, 24, and 48 hours thereafter. Results: There was no significant difference in clinical outcomes between the 2 groups. The operating time was longer and consumption of platelets was greater for the on-pump beating heart group. There was no postoperative mortality or major complication in either group. There was significant elevation in the levels of interleukin-6, interleukin-8, and interleukin-10 and tumor necrosis factor-alpha during and immediately after the operations in the on-pump beating heart group when compared with the off-pump group. Levels of interleukin-8 (P = .01) and tumor necrosis factor-alpha (P = .0004) remained significantly elevated 4 hours after the operation in the on-pump beating heart group. The level of vascular adhesion molecule dropped significantly during the operation but was elevated 4 hours (P = .026) after the operation in the on-pump beating heart group. Conclusion: The use of cardiopulmonary bypass alone without global myocardial ischemia secondary to aortic crossclamping and cardioplegic cardiac arrest can trigger intense inflammatory responses.
Persistent Identifierhttp://hdl.handle.net/10722/196665
ISSN
2015 Impact Factor: 3.494
2015 SCImago Journal Rankings: 2.369
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, IYP-
dc.contributor.authorArifi, AA-
dc.contributor.authorWan, S-
dc.contributor.authorYip, JHY-
dc.contributor.authorSihoe, ADL-
dc.contributor.authorThung, KH-
dc.contributor.authorWong, EMC-
dc.contributor.authorYim, APC-
dc.date.accessioned2014-04-24T02:10:32Z-
dc.date.available2014-04-24T02:10:32Z-
dc.date.issued2004-
dc.identifier.citationJournal of Thoracic and Cardiovascular Surgery, 2004, v. 127 n. 6, p. 1624-1631-
dc.identifier.issn0022-5223-
dc.identifier.urihttp://hdl.handle.net/10722/196665-
dc.description.abstractObjective: On-pump beating heart coronary artery surgery provides the opportunity to examine the isolated effect of cardiopulmonary bypass. This prospective randomized study compares the early clinical outcomes and inflammatory response of patients undergoing elective on-pump and off-pump beating heart coronary artery bypass grafting. Method and Patients: Thirty-seven consecutive patients undergoing elective coronary artery bypass grafting were recruited from a pool of 73 patients, with 19 patients randomized to on-pump beating heart surgery and 18 patients to off-pump coronary bypass surgery. Intraoperative events and postoperative outcomes were recorded. Plasma levels of interleukin-6, interleukin-8, and interleukin-10, tumor necrosis factor-alpha, and vascular cell adhesion molecule-1 were measured before the operation, intraoperatively, after the operation, and 4, 24, and 48 hours thereafter. Results: There was no significant difference in clinical outcomes between the 2 groups. The operating time was longer and consumption of platelets was greater for the on-pump beating heart group. There was no postoperative mortality or major complication in either group. There was significant elevation in the levels of interleukin-6, interleukin-8, and interleukin-10 and tumor necrosis factor-alpha during and immediately after the operations in the on-pump beating heart group when compared with the off-pump group. Levels of interleukin-8 (P = .01) and tumor necrosis factor-alpha (P = .0004) remained significantly elevated 4 hours after the operation in the on-pump beating heart group. The level of vascular adhesion molecule dropped significantly during the operation but was elevated 4 hours (P = .026) after the operation in the on-pump beating heart group. Conclusion: The use of cardiopulmonary bypass alone without global myocardial ischemia secondary to aortic crossclamping and cardioplegic cardiac arrest can trigger intense inflammatory responses.-
dc.languageeng-
dc.relation.ispartofJournal of Thoracic and Cardiovascular Surgery-
dc.titleBeating heart revascularization with or without cardiopulmonary bypass: Evaluation of inflammatory response in a prospective randomized study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jtcvs.2003.10.043-
dc.identifier.pmid15173716-
dc.identifier.scopuseid_2-s2.0-2642558047-
dc.identifier.volume127-
dc.identifier.issue6-
dc.identifier.spage1624-
dc.identifier.epage1631-
dc.identifier.isiWOS:000221895700012-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats