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Article: Induction of NG108-15 cells differrentiation by human bone marrow stromal cells

TitleInduction of NG108-15 cells differrentiation by human bone marrow stromal cells
Authors
Issue Date1998
Citation
NeuroReport, 1998, v. 9 n. 7, p. 1365-1369 How to Cite?
AbstractThe survival and differentiation of neuronal cells is dependent on factors such as neurotrophins, cytokines and components of extracellular matrix. Bone marrow stromal cells have been shown to support the growth and differentiation of neuroblastoma cells. In an attempt to study the effects of bone marrow stromal cells on neuronal differentiation, we have co-cultured neuroblastoma x glioma hybrid NG108-15 cells with human bone marrow stromal cells. After co-culturing, clones exhibiting morphological differentiated phenotype and high level of neurofilament expression were isolated. Interestingly, these clones maintain their ability to proliferate in contrast to differentiated NG108-15 cells induced by dibutyryladenosine 3',5'-cyclic monophosphate. These results suggested that bone marrow stromal cells can induce partial differentiation of NG108-15 cells.
Persistent Identifierhttp://hdl.handle.net/10722/196639
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, S-H-
dc.contributor.authorSo, L-H-
dc.contributor.authorLai, K-O-
dc.contributor.authorIp, NY-
dc.contributor.authorLeung, M-F-
dc.date.accessioned2014-04-24T02:10:30Z-
dc.date.available2014-04-24T02:10:30Z-
dc.date.issued1998-
dc.identifier.citationNeuroReport, 1998, v. 9 n. 7, p. 1365-1369-
dc.identifier.issn0959-4965-
dc.identifier.urihttp://hdl.handle.net/10722/196639-
dc.description.abstractThe survival and differentiation of neuronal cells is dependent on factors such as neurotrophins, cytokines and components of extracellular matrix. Bone marrow stromal cells have been shown to support the growth and differentiation of neuroblastoma cells. In an attempt to study the effects of bone marrow stromal cells on neuronal differentiation, we have co-cultured neuroblastoma x glioma hybrid NG108-15 cells with human bone marrow stromal cells. After co-culturing, clones exhibiting morphological differentiated phenotype and high level of neurofilament expression were isolated. Interestingly, these clones maintain their ability to proliferate in contrast to differentiated NG108-15 cells induced by dibutyryladenosine 3',5'-cyclic monophosphate. These results suggested that bone marrow stromal cells can induce partial differentiation of NG108-15 cells.-
dc.languageeng-
dc.relation.ispartofNeuroReport-
dc.titleInduction of NG108-15 cells differrentiation by human bone marrow stromal cells-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00001756-199805110-00021-
dc.identifier.pmid9631430-
dc.identifier.scopuseid_2-s2.0-0032507634-
dc.identifier.volume9-
dc.identifier.issue7-
dc.identifier.spage1365-
dc.identifier.epage1369-
dc.identifier.isiWOS:000074000000023-

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