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Article: Evolution of PAS domains and PAS-containing genes in eukaryotes

TitleEvolution of PAS domains and PAS-containing genes in eukaryotes
Authors
Issue Date2014
PublisherSpringer Berlin Heidelberg.
Citation
Chromosoma, 2014 How to Cite?
AbstractThe PAS domains are signal modules, which are widely distributed in proteins across all kingdoms of life. They are common in photoreceptors and transcriptional regulators of eukaryotic circadian clocks q(bHLH-PAS proteins and PER in animals; PHY and ZTL in plants; and WC-1, 2, and VVD in fungi) and possess mainly protein–protein interaction and light-sensing functions. We conducted several evolutionary analyses of the PAS superfamily. Although the whole superfamily evolved primarily under strong purifying selection (average ω ranges from 0.0030 to 0.1164), some lineages apparently experienced strong episodic positive selection at some periods of the evolution. Although the PAS domains from different proteins vary in sequence and length, but they maintain a fairly conserved 3D structure, which is determined by only eight residues. The WC-1 and WC- 2, bHLH-PAS, and P er genes probably originated in the Neoproterozoic Era (1000–542 Mya), plant P hy and ZTL evolved in the Paleozoic (541–252 Mya), which might be a result of adaptation to the major climate and global light regime changes having occurred in those eras.
Persistent Identifierhttp://hdl.handle.net/10722/196595
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMEI, Qen_US
dc.contributor.authorDvornyk, Ven_US
dc.date.accessioned2014-04-22T08:39:43Z-
dc.date.available2014-04-22T08:39:43Z-
dc.date.issued2014en_US
dc.identifier.citationChromosoma, 2014en_US
dc.identifier.urihttp://hdl.handle.net/10722/196595-
dc.description.abstractThe PAS domains are signal modules, which are widely distributed in proteins across all kingdoms of life. They are common in photoreceptors and transcriptional regulators of eukaryotic circadian clocks q(bHLH-PAS proteins and PER in animals; PHY and ZTL in plants; and WC-1, 2, and VVD in fungi) and possess mainly protein–protein interaction and light-sensing functions. We conducted several evolutionary analyses of the PAS superfamily. Although the whole superfamily evolved primarily under strong purifying selection (average ω ranges from 0.0030 to 0.1164), some lineages apparently experienced strong episodic positive selection at some periods of the evolution. Although the PAS domains from different proteins vary in sequence and length, but they maintain a fairly conserved 3D structure, which is determined by only eight residues. The WC-1 and WC- 2, bHLH-PAS, and P er genes probably originated in the Neoproterozoic Era (1000–542 Mya), plant P hy and ZTL evolved in the Paleozoic (541–252 Mya), which might be a result of adaptation to the major climate and global light regime changes having occurred in those eras.en_US
dc.languageengen_US
dc.publisherSpringer Berlin Heidelberg.en_US
dc.relation.ispartofChromosomaen_US
dc.titleEvolution of PAS domains and PAS-containing genes in eukaryotesen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.identifier.doi10.1007/s00412-014-0457-xen_US
dc.identifier.pmid24699836-
dc.identifier.hkuros228577en_US
dc.identifier.isiWOS:000339882300006-

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