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Article: Samaritan donor interchange in living donor liver transplantation

TitleSamaritan donor interchange in living donor liver transplantation
Authors
KeywordsLiving donor liver transplantation
Right lobe
Orthotopic liver transplantation
Issue Date2014
PublisherThe First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/
Citation
Hepatobiliary & Pancreatic Diseases International, 2014, v. 13 n. 1, p. 105-109 How to Cite?
AbstractBACKGROUND: In order to overcome ABO blood group incompatibility, paired donor interchange has been practised in living donor liver transplantation. Liver transplantations using grafts donated by Samaritan living donors have been performed in Europe, North America, South Korea, and Hong Kong. Such practice is clearly on strong biological grounds although social and psychological implications could be far-reaching. Local experience has been satisfactory but is still limited. As few centers have this arrangement, its safety and viability are still being assessed under a clinical trial setting. METHODS: Here we report a donor interchange involving an ABO-compatible pair with a universal donor and an ABO-incompatible pair with a universal recipient. This matching was not only a variation but also an extension of the donor interchange scheme. RESULTS: The four operations (two donor hepatectomies and two recipient operations) were successful. All the two donors and the two recipients recovered well. Such donor interchange further supports the altruistic principle of organ donation in contrast to exchange for a gain. CONCLUSIONS: Samaritan donor interchange certainly taxes further the ethical challenge of donor interchange. Although this practice has obvious biological advantages, such advantages have to be weighed against the potential increase in potential psychological risks to the subjects in the interchange. Further ethical and clinical evaluations of local and overseas experiences of donor interchange should guide future clinical practice in utilizing this potential organ source for transplantation. © 2014, Hepatobiliary Pancreat Dis Int. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/196585
ISSN
2015 Impact Factor: 1.724
2015 SCImago Journal Rankings: 0.717
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, SCen_US
dc.contributor.authorChok, KSHen_US
dc.contributor.authorSharr, WWen_US
dc.contributor.authorChan, ACYen_US
dc.contributor.authorTsang, SHen_US
dc.contributor.authorDai, WCen_US
dc.contributor.authorLo, CMen_US
dc.date.accessioned2014-04-22T08:38:05Z-
dc.date.available2014-04-22T08:38:05Z-
dc.date.issued2014en_US
dc.identifier.citationHepatobiliary & Pancreatic Diseases International, 2014, v. 13 n. 1, p. 105-109en_US
dc.identifier.issn1499-3872-
dc.identifier.urihttp://hdl.handle.net/10722/196585-
dc.description.abstractBACKGROUND: In order to overcome ABO blood group incompatibility, paired donor interchange has been practised in living donor liver transplantation. Liver transplantations using grafts donated by Samaritan living donors have been performed in Europe, North America, South Korea, and Hong Kong. Such practice is clearly on strong biological grounds although social and psychological implications could be far-reaching. Local experience has been satisfactory but is still limited. As few centers have this arrangement, its safety and viability are still being assessed under a clinical trial setting. METHODS: Here we report a donor interchange involving an ABO-compatible pair with a universal donor and an ABO-incompatible pair with a universal recipient. This matching was not only a variation but also an extension of the donor interchange scheme. RESULTS: The four operations (two donor hepatectomies and two recipient operations) were successful. All the two donors and the two recipients recovered well. Such donor interchange further supports the altruistic principle of organ donation in contrast to exchange for a gain. CONCLUSIONS: Samaritan donor interchange certainly taxes further the ethical challenge of donor interchange. Although this practice has obvious biological advantages, such advantages have to be weighed against the potential increase in potential psychological risks to the subjects in the interchange. Further ethical and clinical evaluations of local and overseas experiences of donor interchange should guide future clinical practice in utilizing this potential organ source for transplantation. © 2014, Hepatobiliary Pancreat Dis Int. All rights reserved.-
dc.languageengen_US
dc.publisherThe First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/-
dc.relation.ispartofHepatobiliary & Pancreatic Diseases Internationalen_US
dc.subjectLiving donor liver transplantation-
dc.subjectRight lobe-
dc.subjectOrthotopic liver transplantation-
dc.titleSamaritan donor interchange in living donor liver transplantationen_US
dc.typeArticleen_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailChok, KSH: chok6275@hku.hken_US
dc.identifier.emailSharr, WW: wwsharr@hku.hken_US
dc.identifier.emailChan, ACY: acchan@hku.hken_US
dc.identifier.emailDai, WC: daiwc@hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.authorityChan, SC=rp01568en_US
dc.identifier.authorityChan, ACY=rp00310en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.identifier.doi10.1016/S1499-3872(14)60016-3-
dc.identifier.pmid24463089-
dc.identifier.scopuseid_2-s2.0-84902573201-
dc.identifier.hkuros228581en_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.spage105en_US
dc.identifier.epage109en_US
dc.identifier.isiWOS:000330199700016-
dc.publisher.placeChina-

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