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Article: Perfusion and diffusion characteristics of cervical cancer based on intraxovel incoherent motion MR imaging-a pilot study

TitlePerfusion and diffusion characteristics of cervical cancer based on intraxovel incoherent motion MR imaging-a pilot study
Authors
Issue Date2014
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htm
Citation
European Radiology, 2014 How to Cite?
AbstractObjectives To investigate the tissue characteristics of cervical cancer based on intravoxel incoherent motion (IVIM) model and to differentiate cervical cancer from non-malignant tissues based on the IVIM characteristics. Methods Sixteen treatment-naïve cervical cancer and 17 age-matched healthy subjects were prospectively recruited for diffusion-weighted (b=0-1000 s/mm2) and standard pelvic MRI. Bi-exponential analysis was performed to derive the perfusion parameters, f (perfusion fraction), D* (pseudodiffusion coefficient) and the diffusion parameter, D (true molecular diffusion coefficient) in cervical cancer, normal cervix, myometrium and leiomyoma. Apparent diffusion coefficient (ADC) was calculated. Kruskal-Wallis test and receiver operating characteristics (ROC) curves were used. Results Cervical cancer had the lowest f (14.9±2.6%), significantly different from normal cervix and leiomyoma (p<0.05). The D (0.86±0.16 x 103 mm2/s) was also lowest in cervical cancer, significantly different from normal cervix and myometrium (p<0.05) but not with leiomyoma. No difference was observed in D*. D was consistently lower than ADC in all tissues. ROC curves identified f < 16.38%, D < 1.04 x 103 mm2/s and ADC <1.13 x 103 mm2/s could differentiate cervical cancer from non-malignant tissues (AUC: 0.773-0.908). Conclusions Cervical cancer has low perfusion and diffusion IVIM characteristics that allow differentiation from non-malignant tissues.
Persistent Identifierhttp://hdl.handle.net/10722/196562
ISSN
2015 Impact Factor: 3.64
2015 SCImago Journal Rankings: 2.064

 

DC FieldValueLanguage
dc.contributor.authorLee, EYPen_US
dc.contributor.authorYU, Xen_US
dc.contributor.authorChu, MMYen_US
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorSiu, SWKen_US
dc.contributor.authorSoong, ISen_US
dc.contributor.authorChan, Qen_US
dc.contributor.authorKhong, PLen_US
dc.date.accessioned2014-04-22T08:35:52Z-
dc.date.available2014-04-22T08:35:52Z-
dc.date.issued2014en_US
dc.identifier.citationEuropean Radiology, 2014en_US
dc.identifier.issn0938-7994en_US
dc.identifier.urihttp://hdl.handle.net/10722/196562-
dc.description.abstractObjectives To investigate the tissue characteristics of cervical cancer based on intravoxel incoherent motion (IVIM) model and to differentiate cervical cancer from non-malignant tissues based on the IVIM characteristics. Methods Sixteen treatment-naïve cervical cancer and 17 age-matched healthy subjects were prospectively recruited for diffusion-weighted (b=0-1000 s/mm2) and standard pelvic MRI. Bi-exponential analysis was performed to derive the perfusion parameters, f (perfusion fraction), D* (pseudodiffusion coefficient) and the diffusion parameter, D (true molecular diffusion coefficient) in cervical cancer, normal cervix, myometrium and leiomyoma. Apparent diffusion coefficient (ADC) was calculated. Kruskal-Wallis test and receiver operating characteristics (ROC) curves were used. Results Cervical cancer had the lowest f (14.9±2.6%), significantly different from normal cervix and leiomyoma (p<0.05). The D (0.86±0.16 x 103 mm2/s) was also lowest in cervical cancer, significantly different from normal cervix and myometrium (p<0.05) but not with leiomyoma. No difference was observed in D*. D was consistently lower than ADC in all tissues. ROC curves identified f < 16.38%, D < 1.04 x 103 mm2/s and ADC <1.13 x 103 mm2/s could differentiate cervical cancer from non-malignant tissues (AUC: 0.773-0.908). Conclusions Cervical cancer has low perfusion and diffusion IVIM characteristics that allow differentiation from non-malignant tissues.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htmen_US
dc.relation.ispartofEuropean Radiologyen_US
dc.rightsThe original publication is available at www.springerlink.comen_US
dc.titlePerfusion and diffusion characteristics of cervical cancer based on intraxovel incoherent motion MR imaging-a pilot studyen_US
dc.typeArticleen_US
dc.identifier.emailLee, EYP: eyplee77@hku.hken_US
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_US
dc.identifier.emailKhong, PL: plkhong@hku.hken_US
dc.identifier.authorityLee, EYP=rp01456en_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.identifier.authorityKhong, PL=rp00467en_US
dc.identifier.hkuros228544en_US
dc.publisher.placeGermanyen_US

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