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Conference Paper: A novel mouse model of vascular cognitive impairment: a diffusional kurtosis imaging study

TitleA novel mouse model of vascular cognitive impairment: a diffusional kurtosis imaging study
Authors
Issue Date2014
PublisherISMRM-ESMRMB 2014.
Citation
The 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014. How to Cite?
AbstractCerebral small vessel disease (SVD) is frequently found in patients with vascular dementia and Alzheimer’s disease. Microinfarcts are hallmarks of SVD, and their gradual accumulation in the brain is strongly correlated with cognitive impairment. Microinfarcts may be useful biomarkers for early detection of cognitive decline. The objective of this study is to investigate spatiotemporal changes in MRI signals associated with murine microinfarcts using DKI. Our preliminary results indicate that microinfarcts are only visible over a short duration (3 days) after vascular occlusion. Methods to prolong and enhance the visibility of microinfarcts will be useful to improve detection in humans.
DescriptionElectronic Poster Session - Neuro 1: Animal Models of Brain: no. 3489
Persistent Identifierhttp://hdl.handle.net/10722/196299

 

DC FieldValueLanguage
dc.contributor.authorHui, ESen_US
dc.contributor.authorShih, AYen_US
dc.date.accessioned2014-04-01T08:46:20Z-
dc.date.available2014-04-01T08:46:20Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014.en_US
dc.identifier.urihttp://hdl.handle.net/10722/196299-
dc.descriptionElectronic Poster Session - Neuro 1: Animal Models of Brain: no. 3489-
dc.description.abstractCerebral small vessel disease (SVD) is frequently found in patients with vascular dementia and Alzheimer’s disease. Microinfarcts are hallmarks of SVD, and their gradual accumulation in the brain is strongly correlated with cognitive impairment. Microinfarcts may be useful biomarkers for early detection of cognitive decline. The objective of this study is to investigate spatiotemporal changes in MRI signals associated with murine microinfarcts using DKI. Our preliminary results indicate that microinfarcts are only visible over a short duration (3 days) after vascular occlusion. Methods to prolong and enhance the visibility of microinfarcts will be useful to improve detection in humans.-
dc.languageengen_US
dc.publisherISMRM-ESMRMB 2014.-
dc.relation.ispartofISMRM-ESMRMB Annual Meeting 2014en_US
dc.titleA novel mouse model of vascular cognitive impairment: a diffusional kurtosis imaging studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailHui, ES: edshui@hku.hken_US
dc.identifier.authorityHui, ES=rp01832en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros228428en_US
dc.publisher.placeItaly-

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