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Article: Gain-of-function experiments on H7N9

TitleGain-of-function experiments on H7N9
Authors
Issue Date2013
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2013, v. 341 n. 6146, p. 612-613 How to Cite?
AbstractSince the end of March 2013, avian a influenza viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were severe, resulting in 43 fatalities. Although this A(H7N9) virus outbreak is now under control, the virus (or one with similar properties) could reemerge as winter approaches. To better assess the pandemic threat posed by A(H7N9) viruses, NIAID/NIH Centers of Excellence in Influenza Research and Surveillance (CEIRS) investigators and other expert laboratories in China and elsewhere have characterized the wild-type avian A(H7N9) viruses in terms of host range, virulence, and transmission, and are evaluating the effectiveness of antiviral drugs and vaccine candidates. However, to fully assess the potential risk associated with these novel viruses, there is a need for additional research including experiments that may be classified as 'gain-of-function' (GOF). Here, we outline the aspects of the current situation that most urgently require additional research, our proposed studies, and risk-mitigation strategies.
Persistent Identifierhttp://hdl.handle.net/10722/195759
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217

 

DC FieldValueLanguage
dc.contributor.authorFouchier, RAen_US
dc.contributor.authorKawaoka, Yen_US
dc.contributor.authorCardona, Cen_US
dc.contributor.authorCompans, RWen_US
dc.contributor.authorGarcía-Sastre, Aen_US
dc.contributor.authorGovorkova, EAen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorHerfst, Sen_US
dc.contributor.authorOrenstein, WAen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorPerez, DRen_US
dc.contributor.authorRicht, JAen_US
dc.contributor.authorRussell, Cen_US
dc.contributor.authorSchultz-Cherry, SLen_US
dc.contributor.authorSmith, DJen_US
dc.contributor.authorSteel, Jen_US
dc.contributor.authorTompkins, SMen_US
dc.contributor.authorTopham, DJen_US
dc.contributor.authorTreanor, JJen_US
dc.contributor.authorTripp, RAen_US
dc.contributor.authorWebby, RJen_US
dc.contributor.authorWebster, RGen_US
dc.date.accessioned2014-03-07T04:35:12Z-
dc.date.available2014-03-07T04:35:12Z-
dc.date.issued2013en_US
dc.identifier.citationScience, 2013, v. 341 n. 6146, p. 612-613en_US
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/195759-
dc.description.abstractSince the end of March 2013, avian a influenza viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were severe, resulting in 43 fatalities. Although this A(H7N9) virus outbreak is now under control, the virus (or one with similar properties) could reemerge as winter approaches. To better assess the pandemic threat posed by A(H7N9) viruses, NIAID/NIH Centers of Excellence in Influenza Research and Surveillance (CEIRS) investigators and other expert laboratories in China and elsewhere have characterized the wild-type avian A(H7N9) viruses in terms of host range, virulence, and transmission, and are evaluating the effectiveness of antiviral drugs and vaccine candidates. However, to fully assess the potential risk associated with these novel viruses, there is a need for additional research including experiments that may be classified as 'gain-of-function' (GOF). Here, we outline the aspects of the current situation that most urgently require additional research, our proposed studies, and risk-mitigation strategies.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org-
dc.relation.ispartofScienceen_US
dc.rightsScience. Copyright © American Association for the Advancement of Science.-
dc.titleGain-of-function experiments on H7N9en_US
dc.typeArticleen_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.identifier.doi10.1126/science.1243325en_US
dc.identifier.pmid23929965-
dc.identifier.hkuros228200en_US
dc.identifier.volume341en_US
dc.identifier.issue6146en_US
dc.identifier.spage612en_US
dc.identifier.epage613en_US
dc.publisher.placeUnited States-

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