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Article: Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke

TitleGarlic intake is an independent predictor of endothelial function in patients with ischemic stroke
Authors
Issue Date2013
PublisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603
Citation
Journal of Nutrition, Health and Aging, 2013, v. 17 n. 7, p. 600-604 How to Cite?
AbstractOBJECTIVES: To investigate the effects of garlic on endothelial function in patients with ischemic stroke (ISS). DESIGN: Cross-sectional study. PARTICIPANTS: 125 Chinese patients with prior ISS due to athero-thrombotic disease were recruited from the outpatient clinics during July 2005 to December 2006. MEASUREMENTS: Daily allium vegetable intake (including garlic, onions, Chinese chives and shallots) was ascertained by means of a validated food frequency questionnaire for Chinese and brachial artery flow-mediated dilatation (FMD) was measured using high-resolution ultrasound in all subjects. RESULTS: The mean age of the study population was 65.9+/-11.1 years and 69% were males. Mean allium vegetable intake and garlic intake of the study population was 7.5+/-12.7g/day and 2.9+/-8.8g/day respectively. Their mean FMD was 2.6+/-2.3%. Daily intake of total allium vegetable (r=0.36, P<0.01) and garlic (r=0.34, P<0.01) significantly correlated with FMD. Using the median daily allium intake as cut-off (3.37g/day), patients with a low allium intake <3.37g/day was noted to have a lower FMD compared to those with a normal allium intake (2.1+/-2.1% versus 3.0+/-2.4%, P<0.05). After adjusting for confounding factors, multi-variate analysis identified that daily allium vegetable (B=0.05, 95% confidence interval: 0.02, 0.09, P<0.01) and garlic (B=0.07, 95% confidence interval: 0.02, 0.12, P<0.01) intake, but not onions, Chinese chives and shallots were independent predictors for changes in FMD in patients with ISS. CONCLUSIONS: Daily garlic intake is an independent predictor of endothelial function in patients with ISS and may play a role in the secondary prevention of atherosclerotic events.
Persistent Identifierhttp://hdl.handle.net/10722/195642
ISSN
2015 Impact Factor: 3.199
2015 SCImago Journal Rankings: 0.919
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, GKK-
dc.contributor.authorChan, YH-
dc.contributor.authorWong, YK-
dc.contributor.authorTeo, KC-
dc.contributor.authorYiu, KH-
dc.contributor.authorLiu, S-
dc.contributor.authorLi, LS-
dc.contributor.authorShu, XO-
dc.contributor.authorHo, SL-
dc.contributor.authorChan, KH-
dc.contributor.authorSiu, DCW-
dc.contributor.authorTse, HF-
dc.date.accessioned2014-03-07T02:48:04Z-
dc.date.available2014-03-07T02:48:04Z-
dc.date.issued2013-
dc.identifier.citationJournal of Nutrition, Health and Aging, 2013, v. 17 n. 7, p. 600-604-
dc.identifier.issn1279-7707-
dc.identifier.urihttp://hdl.handle.net/10722/195642-
dc.description.abstractOBJECTIVES: To investigate the effects of garlic on endothelial function in patients with ischemic stroke (ISS). DESIGN: Cross-sectional study. PARTICIPANTS: 125 Chinese patients with prior ISS due to athero-thrombotic disease were recruited from the outpatient clinics during July 2005 to December 2006. MEASUREMENTS: Daily allium vegetable intake (including garlic, onions, Chinese chives and shallots) was ascertained by means of a validated food frequency questionnaire for Chinese and brachial artery flow-mediated dilatation (FMD) was measured using high-resolution ultrasound in all subjects. RESULTS: The mean age of the study population was 65.9+/-11.1 years and 69% were males. Mean allium vegetable intake and garlic intake of the study population was 7.5+/-12.7g/day and 2.9+/-8.8g/day respectively. Their mean FMD was 2.6+/-2.3%. Daily intake of total allium vegetable (r=0.36, P<0.01) and garlic (r=0.34, P<0.01) significantly correlated with FMD. Using the median daily allium intake as cut-off (3.37g/day), patients with a low allium intake <3.37g/day was noted to have a lower FMD compared to those with a normal allium intake (2.1+/-2.1% versus 3.0+/-2.4%, P<0.05). After adjusting for confounding factors, multi-variate analysis identified that daily allium vegetable (B=0.05, 95% confidence interval: 0.02, 0.09, P<0.01) and garlic (B=0.07, 95% confidence interval: 0.02, 0.12, P<0.01) intake, but not onions, Chinese chives and shallots were independent predictors for changes in FMD in patients with ISS. CONCLUSIONS: Daily garlic intake is an independent predictor of endothelial function in patients with ISS and may play a role in the secondary prevention of atherosclerotic events.-
dc.languageeng-
dc.publisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603-
dc.relation.ispartofJournal of Nutrition, Health and Aging-
dc.rightsThe original publication is available at www.springerlink.com-
dc.titleGarlic intake is an independent predictor of endothelial function in patients with ischemic strokeen_US
dc.typeArticleen_US
dc.identifier.emailLau, GKK: gkklau@hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailHo, SL: slho@hku.hk, slho@hkucc.hku.hk-
dc.identifier.emailChan, KH: koonho@hkucc.hku.hk-
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12603-013-0043-6-
dc.identifier.pmid23933870-
dc.identifier.hkuros228289-
dc.identifier.volume17-
dc.identifier.issue7-
dc.identifier.spage600-
dc.identifier.epage604-
dc.identifier.isiWOS:000325022200003-
dc.publisher.placeFrance-

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