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Article: Novel heavy tamponade for vitreoretinal surgery

TitleNovel heavy tamponade for vitreoretinal surgery
Authors
Issue Date2013
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology & Visual Science, 2013, v. 54 n. 12, p. 7284-7292 How to Cite?
AbstractPURPOSE: The aim of this study was to produce a heavy tamponade with a specific gravity greater than 1.06 g/mL that was optically transparent, could be manufactured using simple processing, could be injected using standard clinical equipment, and would have appropriate biocompatibility. METHODS: Aerosil silica was added to a phenyl trimethicone and mixed via a roller, overhead stirring, and ultrasonics. The refractive index, visible absorbance, and shear viscosity were measured. The injectability of the solutions was evaluated using the Accurus Viscous Fluid Injection system. The tamponade efficiency was assessed using a model eye chamber and compared with that of Densiron 68, Oxane HD, and F6H8. The biocompatibility was evaluated in vitro and in vivo in rabbits. RESULTS: Tamponade agents were produced with specific gravities of 1.10, 1.11, 1.13, and 1.16 g/mL that had good optical clarity. Mixing using overhead stirring was sufficient to produce tamponade agents with shear viscosities in the range 1000 to 5000 mPa.s that were reproducible and stable during storage. The solutions were easier to inject using the Accurus Viscous Fluid Injection system than silicone oil 1000 mPa.s. The 11% silica solution had greater tamponade efficiency than Densiron 68 or Oxane HD. There was no evidence of cytotoxicity in vitro. Silica solution 11% induced cataract earlier than Polydimethylsiloxane 1000 (PDMS 1000). Silica solution 11% and phenyl trimethicone reduced the a-wave value at 1 week after vitrectomy, but recovery was observed at later time points. Silica solution 11% caused inner nuclear layer (INL) nuclei dropdown in inferior retina from 4 weeks postoperation. Polydimethylsiloxane 1000 induced a similar phenomenon in superior retina 12 weeks postoperation. CONCLUSIONS: We have produced a heavy tamponade with good clarity that has appropriate shear viscosity, injectibility, enhanced tamponade efficiency, and biocompatibility similar to that of PDMS 1000.
Persistent Identifierhttp://hdl.handle.net/10722/195535
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWilliams, RL-
dc.contributor.authorKearns, VR-
dc.contributor.authorLo, AC-
dc.contributor.authorDay, M-
dc.contributor.authorGarvey, MJ-
dc.contributor.authorKrishna, Y-
dc.contributor.authorMa, D-
dc.contributor.authorStappler, T-
dc.contributor.authorWong, DSH-
dc.date.accessioned2014-03-03T02:54:45Z-
dc.date.available2014-03-03T02:54:45Z-
dc.date.issued2013-
dc.identifier.citationInvestigative Ophthalmology & Visual Science, 2013, v. 54 n. 12, p. 7284-7292-
dc.identifier.issn0146-0404-
dc.identifier.urihttp://hdl.handle.net/10722/195535-
dc.description.abstractPURPOSE: The aim of this study was to produce a heavy tamponade with a specific gravity greater than 1.06 g/mL that was optically transparent, could be manufactured using simple processing, could be injected using standard clinical equipment, and would have appropriate biocompatibility. METHODS: Aerosil silica was added to a phenyl trimethicone and mixed via a roller, overhead stirring, and ultrasonics. The refractive index, visible absorbance, and shear viscosity were measured. The injectability of the solutions was evaluated using the Accurus Viscous Fluid Injection system. The tamponade efficiency was assessed using a model eye chamber and compared with that of Densiron 68, Oxane HD, and F6H8. The biocompatibility was evaluated in vitro and in vivo in rabbits. RESULTS: Tamponade agents were produced with specific gravities of 1.10, 1.11, 1.13, and 1.16 g/mL that had good optical clarity. Mixing using overhead stirring was sufficient to produce tamponade agents with shear viscosities in the range 1000 to 5000 mPa.s that were reproducible and stable during storage. The solutions were easier to inject using the Accurus Viscous Fluid Injection system than silicone oil 1000 mPa.s. The 11% silica solution had greater tamponade efficiency than Densiron 68 or Oxane HD. There was no evidence of cytotoxicity in vitro. Silica solution 11% induced cataract earlier than Polydimethylsiloxane 1000 (PDMS 1000). Silica solution 11% and phenyl trimethicone reduced the a-wave value at 1 week after vitrectomy, but recovery was observed at later time points. Silica solution 11% caused inner nuclear layer (INL) nuclei dropdown in inferior retina from 4 weeks postoperation. Polydimethylsiloxane 1000 induced a similar phenomenon in superior retina 12 weeks postoperation. CONCLUSIONS: We have produced a heavy tamponade with good clarity that has appropriate shear viscosity, injectibility, enhanced tamponade efficiency, and biocompatibility similar to that of PDMS 1000.-
dc.languageeng-
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org-
dc.relation.ispartofInvestigative Ophthalmology & Visual Science-
dc.subject.meshEndotamponade - methods-
dc.subject.meshSilicon Dioxide - administration and dosage-
dc.subject.meshSilicone Oils - administration and dosage - chemistry-
dc.subject.meshSpectrophotometry-
dc.subject.meshVitreoretinal Surgery - methods-
dc.titleNovel heavy tamponade for vitreoretinal surgeryen_US
dc.typeArticleen_US
dc.identifier.emailWong, DSH: shdwong@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1167/iovs.13-11876-
dc.identifier.pmid24130181-
dc.identifier.hkuros230922-
dc.identifier.volume54-
dc.identifier.issue12-
dc.identifier.spage7284-
dc.identifier.epage7292-
dc.identifier.isiWOS:000327949700014-
dc.publisher.placeUnited States-

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