File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prednisolone and chlorambucil treatment in idiopathic membranous nephropathy with deteriorating renal function

TitlePrednisolone and chlorambucil treatment in idiopathic membranous nephropathy with deteriorating renal function
Authors
Issue Date1988
Citation
Lancet, 1988, v. 2 n. 8616, p. 869-872 How to Cite?
AbstractEight patients with idiopathic membranous nephropathy whose renal function was deteriorating were given a 6-month course of alternating monthly cycles of prednisolone and chlorambucil. Proteinuria was reduced in all eight, from a mean (SD) of 15.3 (5.9) g/24 h at the start of the treatment to 2.1 (1.5) g/24 h at follow-up (p < 0.05). Creatinine clearance increased in six, and the rate of decline was reduced in the other two (group mean 51.6 [17.8] ml/min at the start of treatment and 81.4 [36.8] ml/min at follow-up; p < 0.05). Adverse effects of chlorambucil were severe, and the daily dose had to be reduced. Prednisolone and chlorambucil treatment can change the natural course of membranous nephropathy even when renal function has started to deteriorate, so treatment can be reserved for high-risk patients.
Persistent Identifierhttp://hdl.handle.net/10722/195525
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMathieson, PW-
dc.contributor.authorMaidment, CGH-
dc.contributor.authorTurner, AN-
dc.contributor.authorEvans, DJ-
dc.contributor.authorRees, AJ-
dc.date.accessioned2014-02-28T06:12:16Z-
dc.date.available2014-02-28T06:12:16Z-
dc.date.issued1988-
dc.identifier.citationLancet, 1988, v. 2 n. 8616, p. 869-872-
dc.identifier.issn0140-6736-
dc.identifier.urihttp://hdl.handle.net/10722/195525-
dc.description.abstractEight patients with idiopathic membranous nephropathy whose renal function was deteriorating were given a 6-month course of alternating monthly cycles of prednisolone and chlorambucil. Proteinuria was reduced in all eight, from a mean (SD) of 15.3 (5.9) g/24 h at the start of the treatment to 2.1 (1.5) g/24 h at follow-up (p < 0.05). Creatinine clearance increased in six, and the rate of decline was reduced in the other two (group mean 51.6 [17.8] ml/min at the start of treatment and 81.4 [36.8] ml/min at follow-up; p < 0.05). Adverse effects of chlorambucil were severe, and the daily dose had to be reduced. Prednisolone and chlorambucil treatment can change the natural course of membranous nephropathy even when renal function has started to deteriorate, so treatment can be reserved for high-risk patients.-
dc.languageeng-
dc.relation.ispartofLancet-
dc.titlePrednisolone and chlorambucil treatment in idiopathic membranous nephropathy with deteriorating renal function-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid2902317-
dc.identifier.scopuseid_2-s2.0-0023729887-
dc.identifier.volume2-
dc.identifier.issue8616-
dc.identifier.spage869-
dc.identifier.epage872-
dc.identifier.isiWOS:A1988Q436600003-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats