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Article: Angiopoietins: Microvascular modulators with potential roles in glomerular pathophysiology

TitleAngiopoietins: Microvascular modulators with potential roles in glomerular pathophysiology
Authors
Issue Date2003
Citation
Journal of Nephrology, 2003, v. 16 n. 2, p. 168-178 How to Cite?
AbstractAngiopoietins are a recently discovered family of growth factors which act on endothelial cells via Tie receptors. They are widely expressed and have essential roles in regulating vascular growth, development, maturation and permeability. Disturbances in microvascular regulation play an important part in a number of diseases prominent in the developed world including diabetes, ischemic heart disease and cancer. It is the interplay between angiopoietins and other factors including vascular endothelial growth factor (VEGF) which determines endothelial behavior both in health and in these diseases. Angiopoietin-1 is unique in its ability to reduce endothelial permeability and it antagonises the effects of VEGF in its permeability and angiogenesis-inducing actions. The renal glomerulus constitutes a highly specialized microcirculation in which the permeability characteristics of the capillary wall allow its unique filtration function. Disturbance of this function may cause a reduction hi glomerular filtration rate or proteinuria. Understanding of the regulation of the filtration barrier is incomplete but the expression of angiopoietins in the glomerulus suggests a mechanism for maintenance of the glomerular endothelium and modulation of the actions of glomerular VEGF. As has been clearly shown for VEGF, angiopoietins are likely to be involved in glomerular disease and recovery from it. Manipulation of angiopoietins has a wide range of potential therapeutic applications from inhibition of diabetic retinal neovascularisation to promotion of glomerular repair.
Persistent Identifierhttp://hdl.handle.net/10722/195386
ISSN
2015 Impact Factor: 1.352
2015 SCImago Journal Rankings: 0.689
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSatchell, SC-
dc.contributor.authorMathieson, PW-
dc.date.accessioned2014-02-28T06:12:04Z-
dc.date.available2014-02-28T06:12:04Z-
dc.date.issued2003-
dc.identifier.citationJournal of Nephrology, 2003, v. 16 n. 2, p. 168-178-
dc.identifier.issn1121-8428-
dc.identifier.urihttp://hdl.handle.net/10722/195386-
dc.description.abstractAngiopoietins are a recently discovered family of growth factors which act on endothelial cells via Tie receptors. They are widely expressed and have essential roles in regulating vascular growth, development, maturation and permeability. Disturbances in microvascular regulation play an important part in a number of diseases prominent in the developed world including diabetes, ischemic heart disease and cancer. It is the interplay between angiopoietins and other factors including vascular endothelial growth factor (VEGF) which determines endothelial behavior both in health and in these diseases. Angiopoietin-1 is unique in its ability to reduce endothelial permeability and it antagonises the effects of VEGF in its permeability and angiogenesis-inducing actions. The renal glomerulus constitutes a highly specialized microcirculation in which the permeability characteristics of the capillary wall allow its unique filtration function. Disturbance of this function may cause a reduction hi glomerular filtration rate or proteinuria. Understanding of the regulation of the filtration barrier is incomplete but the expression of angiopoietins in the glomerulus suggests a mechanism for maintenance of the glomerular endothelium and modulation of the actions of glomerular VEGF. As has been clearly shown for VEGF, angiopoietins are likely to be involved in glomerular disease and recovery from it. Manipulation of angiopoietins has a wide range of potential therapeutic applications from inhibition of diabetic retinal neovascularisation to promotion of glomerular repair.-
dc.languageeng-
dc.relation.ispartofJournal of Nephrology-
dc.titleAngiopoietins: Microvascular modulators with potential roles in glomerular pathophysiology-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12768063-
dc.identifier.scopuseid_2-s2.0-0043022164-
dc.identifier.volume16-
dc.identifier.issue2-
dc.identifier.spage168-
dc.identifier.epage178-
dc.identifier.isiWOS:000182734200002-

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