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  Patent History
  • Application
    CA 20082699642 2008-09-11
  • Publication
    CA 2699642 2009-03-19

published patent: COMPOSITIONS AND METHODS FOR IMPROVING THE FUNCTIONAL EFFICACY OF STEM CELL-DERIVED CARDIOMYOCYTES

TitleCOMPOSITIONS AND METHODS FOR IMPROVING THE FUNCTIONAL EFFICACY OF STEM CELL-DERIVED CARDIOMYOCYTES
Priority Date2007-09-12 US 11/971855P
2008-09-11 PCT/US2008076084
Inventors
Issue Date2009
Citation
Canada Published Patent Application CA 2699642. Gatineau, Quebec: Canadian Intellectual Property Office (CIPO), 2009 How to Cite?
AbstractThis invention provides an isolated stem cell modified to provide, enhance or contain the functional characteristics of the sarcoplasmic reticulum (SR) The isolated stem cells are modified by expressing a calcium channel protein, by expressing a calcium pump protein such as the sarcro/endoplasmic reticulum Ca2+-ATPase (SERCA) protein, by inhibiting or downregulating expression of the Na+/Ca2+ exchanger (NCX) protein, by expressing a calcium handling protein, by expressing a transverse (t)-tubule, and/or by expressing a transverse (t)-tubule biogenic protein The modified cells may be expanded to a substantially homogenous population of these cells or differentiated to a more mature cell type Compositions are also provided The cells and compositions can be administered to a host and used to regenerate cardiac tissue, improve cardiac function, restore action potential of cardiac tissue, and treat or prevent cardiac malfunction Use for diagnostic screening of therapeutic candidates is also provided
Persistent Identifierhttp://hdl.handle.net/10722/195312

 

DC FieldValueLanguage
dc.date.accessioned2014-02-28T01:05:08Z-
dc.date.available2014-02-28T01:05:08Z-
dc.date.issued2009-
dc.identifier.citationCanada Published Patent Application CA 2699642. Gatineau, Quebec: Canadian Intellectual Property Office (CIPO), 2009-
dc.identifier.urihttp://hdl.handle.net/10722/195312-
dc.description.abstractThis invention provides an isolated stem cell modified to provide, enhance or contain the functional characteristics of the sarcoplasmic reticulum (SR) The isolated stem cells are modified by expressing a calcium channel protein, by expressing a calcium pump protein such as the sarcro/endoplasmic reticulum Ca2+-ATPase (SERCA) protein, by inhibiting or downregulating expression of the Na+/Ca2+ exchanger (NCX) protein, by expressing a calcium handling protein, by expressing a transverse (t)-tubule, and/or by expressing a transverse (t)-tubule biogenic protein The modified cells may be expanded to a substantially homogenous population of these cells or differentiated to a more mature cell type Compositions are also provided The cells and compositions can be administered to a host and used to regenerate cardiac tissue, improve cardiac function, restore action potential of cardiac tissue, and treat or prevent cardiac malfunction Use for diagnostic screening of therapeutic candidates is also provideden_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documentsen_US
dc.titleCOMPOSITIONS AND METHODS FOR IMPROVING THE FUNCTIONAL EFFICACY OF STEM CELL-DERIVED CARDIOMYOCYTESen_US
dc.typePatent-
dc.description.naturepublished_or_final_version-
dc.contributor.inventorLI, RONALDen_US
dc.contributor.inventorSIU, CHUNG-WAHen_US
dc.contributor.inventorLIEU, DEBORAH Ken_US
dc.contributor.inventorLIU, JINGen_US
patents.identifier.applicationCA 20082699642en_US
patents.description.assigneeUNIV CALIFORNIA [US]en_US
patents.description.countryCanadaen_US
patents.date.publication2009-03-19en_US
patents.date.application2008-09-11en_US
patents.date.priority2007-09-12 US 11/971855Pen_US
patents.date.priority2008-09-11 PCT/US2008076084en_US
patents.description.cccaen_US
patents.identifier.publicationCA 2699642en_US
patents.relation.familyEP 2198010 (A2) 2010-06-23en_US
patents.relation.familyUS 2012014924 (A1) 2012-01-19en_US
patents.relation.familyWO 2009036220 (A2) 2009-03-19en_US
patents.description.kindA1en_US
patents.typePatent_publisheden_US

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