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Conference Paper: Direct evidence for decreased intra-axonal diffusivity in ischemic human stroke

TitleDirect evidence for decreased intra-axonal diffusivity in ischemic human stroke
Authors
Issue Date2012
Citation
ISMRM 20th Annual Meeting, 2012 How to Cite?
AbstractThe decrease of the water diffusion coefficient in ischemic stroke provides a sensitive and reliable diagnostic tool. However, the underlying biophysical mechanisms for the diffusion drop are still not fully understood. In this study, we characterize changes in the white matter microstructure in human subacute stroke by applying a recently developed white matter model for diffusional kurtosis imaging, which yields estimates for the intra-axonal and extra-axonal diffusivities and for the axonal water fraction. A large change of 55% is observed in the intra-axonal diffusivity, consistent with axonal beading as a primary mechanism underlying the diffusion drop associated with ischemia.
Persistent Identifierhttp://hdl.handle.net/10722/195272

 

DC FieldValueLanguage
dc.contributor.authorFieremans, Een_US
dc.contributor.authorJensen, JHen_US
dc.contributor.authorHui, SKen_US
dc.contributor.authorNovikov, DSen_US
dc.contributor.authorTabesh, Aen_US
dc.contributor.authorBonilha, Len_US
dc.contributor.authorHelpern, JAen_US
dc.date.accessioned2014-02-26T02:07:49Z-
dc.date.available2014-02-26T02:07:49Z-
dc.date.issued2012en_US
dc.identifier.citationISMRM 20th Annual Meeting, 2012en_US
dc.identifier.urihttp://hdl.handle.net/10722/195272-
dc.description.abstractThe decrease of the water diffusion coefficient in ischemic stroke provides a sensitive and reliable diagnostic tool. However, the underlying biophysical mechanisms for the diffusion drop are still not fully understood. In this study, we characterize changes in the white matter microstructure in human subacute stroke by applying a recently developed white matter model for diffusional kurtosis imaging, which yields estimates for the intra-axonal and extra-axonal diffusivities and for the axonal water fraction. A large change of 55% is observed in the intra-axonal diffusivity, consistent with axonal beading as a primary mechanism underlying the diffusion drop associated with ischemia.en_US
dc.languageengen_US
dc.relation.ispartofISMRM 20th Annual Meetingen_US
dc.titleDirect evidence for decreased intra-axonal diffusivity in ischemic human strokeen_US
dc.typeConference_Paperen_US
dc.identifier.emailHui, SK: edshui@hku.hken_US
dc.identifier.authorityHui, SK=rp01832en_US

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