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Conference Paper: Diffusional kurtosis detects cortical demyelination in the cuprizone mouse model

TitleDiffusional kurtosis detects cortical demyelination in the cuprizone mouse model
Authors
Issue Date2012
Citation
ISMRM 20th Annual Meeting, 2012 How to Cite?
AbstractThe cuprizone mouse model is a well characterized animal model of demyelination. Recently, cortical demyelination has also been observed. Diffusion tensor imaging (DTI) studies have demonstrated the pathology of the corpus callosum (CC) in cuprizone mouse model, but no cortical diffusion changes have been reported. Diffusional Kurtosis Imaging (DKI) quantifies the non-Gaussian behavior of water diffusion, contributing additional information beyond that provided by DTI. Here we report, for the first time, DKI changes in the cortex of mice with demyelination induced by cuprizone, demonstrating the significant advantage of microstructural characterization using DKI, especially for abnormalities in grey matter.
Persistent Identifierhttp://hdl.handle.net/10722/195269

 

DC FieldValueLanguage
dc.contributor.authorHui, SKen_US
dc.contributor.authorHelpern, JAen_US
dc.contributor.authorGuilfoyle, Den_US
dc.contributor.authorGerum, Sen_US
dc.contributor.authorHu, Cen_US
dc.contributor.authorLaFrancois, Jen_US
dc.contributor.authorNie, Xen_US
dc.contributor.authorJensen, JHen_US
dc.contributor.authorTabesh, Aen_US
dc.contributor.authorFalangola, MFen_US
dc.date.accessioned2014-02-26T02:07:49Z-
dc.date.available2014-02-26T02:07:49Z-
dc.date.issued2012en_US
dc.identifier.citationISMRM 20th Annual Meeting, 2012en_US
dc.identifier.urihttp://hdl.handle.net/10722/195269-
dc.description.abstractThe cuprizone mouse model is a well characterized animal model of demyelination. Recently, cortical demyelination has also been observed. Diffusion tensor imaging (DTI) studies have demonstrated the pathology of the corpus callosum (CC) in cuprizone mouse model, but no cortical diffusion changes have been reported. Diffusional Kurtosis Imaging (DKI) quantifies the non-Gaussian behavior of water diffusion, contributing additional information beyond that provided by DTI. Here we report, for the first time, DKI changes in the cortex of mice with demyelination induced by cuprizone, demonstrating the significant advantage of microstructural characterization using DKI, especially for abnormalities in grey matter.en_US
dc.languageengen_US
dc.relation.ispartofISMRM 20th Annual Meetingen_US
dc.titleDiffusional kurtosis detects cortical demyelination in the cuprizone mouse modelen_US
dc.typeConference_Paperen_US
dc.identifier.emailHui, SK: edshui@hku.hken_US
dc.identifier.authorityHui, SK=rp01832en_US

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