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Article: A novel role for proteomics in the discovery of cell-surface markers on stem cells: Scratching the surface

TitleA novel role for proteomics in the discovery of cell-surface markers on stem cells: Scratching the surface
Authors
Issue Date2008
Citation
Proteomics - Clinical Applications, 2008, v. 2 n. 6, p. 892-903 How to Cite?
AbstractThe concept of cell-based therapy has been advocated as a novel approach for treating diseases or conditions where regeneration of cells, tissue and/or potentially organs is required. A promising source for cell-replacement therapies is provided by stem cells, but the success of this approach will ultimately rely on the ability to isolate primary stem or progenitor cells. Cell-surface protein markers will play a critical role in this step. Current methodologies for the identification of cell-surface protein markers rely primarily on antibody availability and flow cytometry, but many cell-surface proteins remain undetectable. Proteomic technologies now offer the possibility to specifically identify and investigate the cell-surface subproteome in a quantitative and discovery-driven manner. Once a cell surface protein marker panel has been identified by MS and the antibodies become available, the panel should permit the identification, tracking, and/or isolation of stem or progenitor cells that may be appropriate for therapeutics. This review provides a context for the use of proteomics in discovering new cell-surface markers for stem cells. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/195192
ISSN
2015 Impact Factor: 2.959
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGundry, RL-
dc.contributor.authorBoheler, KR-
dc.contributor.authorVan Eyk, JE-
dc.contributor.authorWollscheid, B-
dc.date.accessioned2014-02-25T01:40:17Z-
dc.date.available2014-02-25T01:40:17Z-
dc.date.issued2008-
dc.identifier.citationProteomics - Clinical Applications, 2008, v. 2 n. 6, p. 892-903-
dc.identifier.issn1862-8346-
dc.identifier.urihttp://hdl.handle.net/10722/195192-
dc.description.abstractThe concept of cell-based therapy has been advocated as a novel approach for treating diseases or conditions where regeneration of cells, tissue and/or potentially organs is required. A promising source for cell-replacement therapies is provided by stem cells, but the success of this approach will ultimately rely on the ability to isolate primary stem or progenitor cells. Cell-surface protein markers will play a critical role in this step. Current methodologies for the identification of cell-surface protein markers rely primarily on antibody availability and flow cytometry, but many cell-surface proteins remain undetectable. Proteomic technologies now offer the possibility to specifically identify and investigate the cell-surface subproteome in a quantitative and discovery-driven manner. Once a cell surface protein marker panel has been identified by MS and the antibodies become available, the panel should permit the identification, tracking, and/or isolation of stem or progenitor cells that may be appropriate for therapeutics. This review provides a context for the use of proteomics in discovering new cell-surface markers for stem cells. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.relation.ispartofProteomics - Clinical Applications-
dc.titleA novel role for proteomics in the discovery of cell-surface markers on stem cells: Scratching the surface-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/prca.200780122-
dc.identifier.scopuseid_2-s2.0-46749104456-
dc.identifier.volume2-
dc.identifier.issue6-
dc.identifier.spage892-
dc.identifier.epage903-
dc.identifier.isiWOS:000257183900010-

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