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Article: Analysis of altered genomic expression profiles in the senescent and diseased myocardium using cDNA microarrays

TitleAnalysis of altered genomic expression profiles in the senescent and diseased myocardium using cDNA microarrays
Authors
Issue Date2002
Citation
European Journal of Heart Failure, 2002, v. 4 n. 6, p. 687-697 How to Cite?
AbstractCardiac function deteriorates with aging or disease. Short term, any changes in heart function may be beneficial, but long term the alterations are often detrimental. At a molecular level, functional adaptations involve quantitative and qualitative changes in gene expression. Analysis of all the RNA transcripts present in a cell's population (transcriptome) offers unprecedented opportunities to map these transitions. Microarrays (chips), capable of evaluating thousands of transcripts in one assay, are ideal for transcriptome analyses. Gene expression profiling provides information about the dynamics of total genome expression in response to environmental changes and may point to candidate genes responsible for the cascade of events that result in disease or are a consequence of aging. The aim of this review is to describe how comparisons of cellular transcriptomes by cDNA array based techniques provide information about the dynamics of total gene expression, and how the results can be applied to the study of cardiovascular disease and aging. © 2002 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/195159
ISSN
2015 Impact Factor: 5.135
2015 SCImago Journal Rankings: 3.638
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJuhasz, O-
dc.contributor.authorZhu, Y-
dc.contributor.authorGarg, R-
dc.contributor.authorAnisimov, SV-
dc.contributor.authorBoheler, KR-
dc.date.accessioned2014-02-25T01:40:15Z-
dc.date.available2014-02-25T01:40:15Z-
dc.date.issued2002-
dc.identifier.citationEuropean Journal of Heart Failure, 2002, v. 4 n. 6, p. 687-697-
dc.identifier.issn1388-9842-
dc.identifier.urihttp://hdl.handle.net/10722/195159-
dc.description.abstractCardiac function deteriorates with aging or disease. Short term, any changes in heart function may be beneficial, but long term the alterations are often detrimental. At a molecular level, functional adaptations involve quantitative and qualitative changes in gene expression. Analysis of all the RNA transcripts present in a cell's population (transcriptome) offers unprecedented opportunities to map these transitions. Microarrays (chips), capable of evaluating thousands of transcripts in one assay, are ideal for transcriptome analyses. Gene expression profiling provides information about the dynamics of total genome expression in response to environmental changes and may point to candidate genes responsible for the cascade of events that result in disease or are a consequence of aging. The aim of this review is to describe how comparisons of cellular transcriptomes by cDNA array based techniques provide information about the dynamics of total gene expression, and how the results can be applied to the study of cardiovascular disease and aging. © 2002 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Heart Failure-
dc.titleAnalysis of altered genomic expression profiles in the senescent and diseased myocardium using cDNA microarrays-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1388-9842(02)00169-1-
dc.identifier.pmid12453538-
dc.identifier.scopuseid_2-s2.0-0036896749-
dc.identifier.volume4-
dc.identifier.issue6-
dc.identifier.spage687-
dc.identifier.epage697-
dc.identifier.isiWOS:000179717700003-

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