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Article: Galanin and galanin receptors in embryonic stem cells: Accidental or essential?

TitleGalanin and galanin receptors in embryonic stem cells: Accidental or essential?
Authors
Issue Date2002
Citation
Neuropeptides, 2002, v. 36 n. 4, p. 239-245 How to Cite?
AbstractGalanin is a peptide consisting of 29 (mouse) or 30 (human) amino acids that was recently identified in undifferentiated mouse embryonic stem (ES) cells through transcriptome analyses. Galanin is known to have important modulatory roles in neuronal cells, but it is currently unclear what biological role, if any, galanin has in stem cells. Here we show that galanin transcripts represent a distinguishing molecular feature of embryonic stem cell lines and that all three galanin receptors subtypes are expressed in mouse ES cells (Gal-R2 > Gal-R3 ≫ Gal-R1). Based on cell culture data, galanin in a dose-dependent manner appears to regulate growth characteristics of ES cells, at least partially, through interactions with leukemia inhibitory factor (LIF), a cytokine implicated in the self-renewal process of ES cells. The regulation of ES cell growth can therefore be added to the list of biological processes regulated by this peptide.
Persistent Identifierhttp://hdl.handle.net/10722/195157
ISSN
2015 Impact Factor: 2.726
2015 SCImago Journal Rankings: 1.165
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTarasov, KV-
dc.contributor.authorTarasova, YS-
dc.contributor.authorCrider, DG-
dc.contributor.authorAnisimov, SV-
dc.contributor.authorWobus, AM-
dc.contributor.authorBoheler, KR-
dc.date.accessioned2014-02-25T01:40:15Z-
dc.date.available2014-02-25T01:40:15Z-
dc.date.issued2002-
dc.identifier.citationNeuropeptides, 2002, v. 36 n. 4, p. 239-245-
dc.identifier.issn0143-4179-
dc.identifier.urihttp://hdl.handle.net/10722/195157-
dc.description.abstractGalanin is a peptide consisting of 29 (mouse) or 30 (human) amino acids that was recently identified in undifferentiated mouse embryonic stem (ES) cells through transcriptome analyses. Galanin is known to have important modulatory roles in neuronal cells, but it is currently unclear what biological role, if any, galanin has in stem cells. Here we show that galanin transcripts represent a distinguishing molecular feature of embryonic stem cell lines and that all three galanin receptors subtypes are expressed in mouse ES cells (Gal-R2 > Gal-R3 ≫ Gal-R1). Based on cell culture data, galanin in a dose-dependent manner appears to regulate growth characteristics of ES cells, at least partially, through interactions with leukemia inhibitory factor (LIF), a cytokine implicated in the self-renewal process of ES cells. The regulation of ES cell growth can therefore be added to the list of biological processes regulated by this peptide.-
dc.languageeng-
dc.relation.ispartofNeuropeptides-
dc.titleGalanin and galanin receptors in embryonic stem cells: Accidental or essential?-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0143-4179(02)00050-1-
dc.identifier.pmid12372696-
dc.identifier.scopuseid_2-s2.0-0036701008-
dc.identifier.volume36-
dc.identifier.issue4-
dc.identifier.spage239-
dc.identifier.epage245-
dc.identifier.isiWOS:000178883400001-

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