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Article: Molecular mechanisms of cardiomyocyte aging

TitleMolecular mechanisms of cardiomyocyte aging
Authors
Issue Date2011
Citation
Clinical Science, 2011, v. 121 n. 8, p. 315-329 How to Cite?
AbstractWestern societies are rapidly aging, and cardiovascular diseases are the leading cause of death. In fact, age and cardiovascular diseases are positively correlated, and disease syndromes affecting the heart reach epidemic proportions in the very old. Genetic variations and molecular adaptations are the primary contributors to the onset of cardiovascular disease; however, molecular links between age and heart syndromes are complex and involve much more than the passage of time. Changes in CM (cardiomyocyte) structure and function occur with age and precede anatomical and functional changes in the heart. Concomitant with or preceding some of these cellular changes are alterations in gene expression often linked to signalling cascades that may lead to a loss of CMs or reduced function. An understanding of the intrinsic molecular mechanisms underlying these cascading events has been instrumental in forming our current understanding of how CMs adapt with age. In the present review, we describe the molecular mechanisms underlying CM aging and how these changes may contribute to the development of cardiovascular diseases. © The Authors Journal compilation © 2011 Biochemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/195140
ISSN
2015 Impact Factor: 4.996
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAnna, A-
dc.contributor.authorRiordon, DR-
dc.contributor.authorBoheler, KR-
dc.date.accessioned2014-02-25T01:40:13Z-
dc.date.available2014-02-25T01:40:13Z-
dc.date.issued2011-
dc.identifier.citationClinical Science, 2011, v. 121 n. 8, p. 315-329-
dc.identifier.issn0143-5221-
dc.identifier.urihttp://hdl.handle.net/10722/195140-
dc.description.abstractWestern societies are rapidly aging, and cardiovascular diseases are the leading cause of death. In fact, age and cardiovascular diseases are positively correlated, and disease syndromes affecting the heart reach epidemic proportions in the very old. Genetic variations and molecular adaptations are the primary contributors to the onset of cardiovascular disease; however, molecular links between age and heart syndromes are complex and involve much more than the passage of time. Changes in CM (cardiomyocyte) structure and function occur with age and precede anatomical and functional changes in the heart. Concomitant with or preceding some of these cellular changes are alterations in gene expression often linked to signalling cascades that may lead to a loss of CMs or reduced function. An understanding of the intrinsic molecular mechanisms underlying these cascading events has been instrumental in forming our current understanding of how CMs adapt with age. In the present review, we describe the molecular mechanisms underlying CM aging and how these changes may contribute to the development of cardiovascular diseases. © The Authors Journal compilation © 2011 Biochemical Society.-
dc.languageeng-
dc.relation.ispartofClinical Science-
dc.titleMolecular mechanisms of cardiomyocyte aging-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1042/CS20110115-
dc.identifier.pmid21699498-
dc.identifier.scopuseid_2-s2.0-80052316167-
dc.identifier.volume121-
dc.identifier.issue8-
dc.identifier.spage315-
dc.identifier.epage329-
dc.identifier.isiWOS:000296120400005-

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