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Article: SUV as an adjunct in evaluating disease activity in idiopathic pulmonary fibrosis - a pilot study

TitleSUV as an adjunct in evaluating disease activity in idiopathic pulmonary fibrosis - a pilot study
Authors
Issue Date2014
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmedicinecomm.com
Citation
Nuclear Medicine Communications, 2014, v. 35 n. 6, p. 631-637 How to Cite?
AbstractOBJECTIVE: We hypothesize that the standardized uptake value (SUV) from PET/computed tomography (CT) can act as an adjunct to forced vital capacity (FVC) in evaluating disease status in idiopathic pulmonary fibrosis (IPF). METHODS: Eight consecutive male patients diagnosed with IPF were prospectively recruited to undergo full pulmonary function tests, high-resolution computed tomography of the thorax and PET/CT. The corrected mean SUV (rSUVmean) and corrected maximum SUV (rSUVmax) against the mediastinal blood pool were correlated with clinical parameters. Examinations were repeated 6 months later in six patients (2/8 patients had died) and changes were evaluated. Correlation was assessed by Spearman's rank correlation, and statistical significance was considered when the P-value was less than 0.05. RESULTS: The rSUVmean in IPF was negatively correlated with FVC (r=-0.6, P=0.024) and diffusing capacity for carbon monoxide (r=-0.7, P=0.010). The decline in FVC was associated with an increment in rSUVmax (r=-0.9, P=0.019), but no similar observation was made with total CT score (r=-0.1, P=0.787). CONCLUSION: Pulmonary metabolism, rSUVmean, contributes to the functional status of IPF patients, and changes in rSUVmax may serve as an adjunct surrogate marker to FVC in evaluating the disease status in IPF patients.
Persistent Identifierhttp://hdl.handle.net/10722/194954
ISSN
2015 Impact Factor: 1.453
2015 SCImago Journal Rankings: 0.690
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, EYPen_US
dc.contributor.authorWong, CSen_US
dc.contributor.authorFung, SLen_US
dc.contributor.authorYan, PKCen_US
dc.contributor.authorHo, JCMen_US
dc.date.accessioned2014-02-21T06:40:02Z-
dc.date.available2014-02-21T06:40:02Z-
dc.date.issued2014-
dc.identifier.citationNuclear Medicine Communications, 2014, v. 35 n. 6, p. 631-637en_US
dc.identifier.issn0143-3636-
dc.identifier.urihttp://hdl.handle.net/10722/194954-
dc.description.abstractOBJECTIVE: We hypothesize that the standardized uptake value (SUV) from PET/computed tomography (CT) can act as an adjunct to forced vital capacity (FVC) in evaluating disease status in idiopathic pulmonary fibrosis (IPF). METHODS: Eight consecutive male patients diagnosed with IPF were prospectively recruited to undergo full pulmonary function tests, high-resolution computed tomography of the thorax and PET/CT. The corrected mean SUV (rSUVmean) and corrected maximum SUV (rSUVmax) against the mediastinal blood pool were correlated with clinical parameters. Examinations were repeated 6 months later in six patients (2/8 patients had died) and changes were evaluated. Correlation was assessed by Spearman's rank correlation, and statistical significance was considered when the P-value was less than 0.05. RESULTS: The rSUVmean in IPF was negatively correlated with FVC (r=-0.6, P=0.024) and diffusing capacity for carbon monoxide (r=-0.7, P=0.010). The decline in FVC was associated with an increment in rSUVmax (r=-0.9, P=0.019), but no similar observation was made with total CT score (r=-0.1, P=0.787). CONCLUSION: Pulmonary metabolism, rSUVmean, contributes to the functional status of IPF patients, and changes in rSUVmax may serve as an adjunct surrogate marker to FVC in evaluating the disease status in IPF patients.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmedicinecomm.com-
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.titleSUV as an adjunct in evaluating disease activity in idiopathic pulmonary fibrosis - a pilot studyen_US
dc.typeArticleen_US
dc.identifier.emailLee, EYP: eyplee77@hku.hken_US
dc.identifier.emailWong, CS: drcswong@hku.hken_US
dc.identifier.emailYan, PKC: cpkyan@hku.hken_US
dc.identifier.emailHo, JCM: jhocm@hku.hken_US
dc.identifier.authorityLee, EYP=rp01456en_US
dc.identifier.authorityWong, CS=rp01391en_US
dc.identifier.authorityHo, JCM=rp00258en_US
dc.identifier.doi10.1097/MNM.0000000000000083-
dc.identifier.pmid24472818-
dc.identifier.scopuseid_2-s2.0-84899963044-
dc.identifier.hkuros228073en_US
dc.identifier.volume35-
dc.identifier.issue6-
dc.identifier.spage631-
dc.identifier.epage637-
dc.identifier.isiWOS:000335857400008-
dc.publisher.placeUnited States-

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