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Article: Effect of nerve growth factor on regeneration of goldfish optic axons

TitleEffect of nerve growth factor on regeneration of goldfish optic axons
Authors
Issue Date1982
Citation
Brain Research, 1982, v. 238 n. 2, p. 329-339 How to Cite?
AbstractAxonal outgrowth following a crush of the goldfish optic nerve was enhanced if nerve growth factor (NGF) was administered by intraocular injection or by local application to the lesion site. Various forms of NGF (β, 2.5S and 7S) were effective, producing a 20-40% decrease in the time required for recovery of the startle reaction to a bright line. A corresponding increase in axonal outgrowth was revealed by histological examination of the optic nerves. The effect produced by a single intraocular injection given at the time of the lesion was not further increased by subsequent injections. Up to 14 days after the lesion, the size of the retinal ganglion cell bodies and the incidence of nucleoli detectable by light microscopy were not affected by the NGF treatment.
Persistent Identifierhttp://hdl.handle.net/10722/194891
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYip, HK-
dc.contributor.authorGrafstein, B-
dc.date.accessioned2014-02-17T08:41:12Z-
dc.date.available2014-02-17T08:41:12Z-
dc.date.issued1982-
dc.identifier.citationBrain Research, 1982, v. 238 n. 2, p. 329-339-
dc.identifier.issn0006-8993-
dc.identifier.urihttp://hdl.handle.net/10722/194891-
dc.description.abstractAxonal outgrowth following a crush of the goldfish optic nerve was enhanced if nerve growth factor (NGF) was administered by intraocular injection or by local application to the lesion site. Various forms of NGF (β, 2.5S and 7S) were effective, producing a 20-40% decrease in the time required for recovery of the startle reaction to a bright line. A corresponding increase in axonal outgrowth was revealed by histological examination of the optic nerves. The effect produced by a single intraocular injection given at the time of the lesion was not further increased by subsequent injections. Up to 14 days after the lesion, the size of the retinal ganglion cell bodies and the incidence of nucleoli detectable by light microscopy were not affected by the NGF treatment.-
dc.languageeng-
dc.relation.ispartofBrain Research-
dc.titleEffect of nerve growth factor on regeneration of goldfish optic axons-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0006-8993(82)90108-1-
dc.identifier.pmid7093657-
dc.identifier.scopuseid_2-s2.0-0020031636-
dc.identifier.volume238-
dc.identifier.issue2-
dc.identifier.spage329-
dc.identifier.epage339-
dc.identifier.isiWOS:A1982NP07800002-

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