File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Curcumin inhibits cancer cell migration and invasion in squamous cell carcinoma of the tongue through down-regulation of MMP10

TitleCurcumin inhibits cancer cell migration and invasion in squamous cell carcinoma of the tongue through down-regulation of MMP10
Authors
KeywordsMedical sciences
Experimental medicine, laboratory technique
Issue Date2011
PublisherInternational Institute of Anticancer Research. The Journal's web site is located at iiar@iiar-anticancer.org
Citation
The 4th International Congress of Molecular Medicine, Istanbul, Turkey, 27-30 June, 2011. In in vivo, 2011, v. 25 n. 3, p. 561, abstract no. 249 How to Cite?
AbstractBACKGROUND: Curcumin is a natural polyphenol. Its anticancer effect has been σηοςν in various cancer types, including head and neck squamous cell carcinoma. Our study hypothesized that curcumin may suppress the invasiveness of tongue squamous cell carcinoma (TSCC) through the down-regulation of matrix metalloproteinase 10 (MMP10). METHODS: mRNAmicroarray analysis was performed on HN21B, in response to curcumin. Immunohistochemical staining of MMP10 was performed on a tissue array. MMP10 expression levels were verified by qRT-PCR, Western blotting and immunohistochemical staining on TSCC cell lines. The effect of curcumin on TSCC cell lines was assessed by wound healing, adhesion, migration and invasion assays. RESULTS: Microarray analysis showed that MMP10 was down-regulated by 2.36-fold in HN21B in response to curcumin. In 13 out of 20 cases (65%), the TSCC tissue showed higher MMP10 expression than the adjacent normal tissue. Curcumin treatment of TSCC cell lines resulted in down-regulation of MMP10 gene and protein expression level in a dose-dependent manner. Curcumin also suppressed adhesion, migration and invasion of TSCC cell lines. CONCLUSION: Curcumin treatment reduced MMP10 expression level in TSCC cell lines. This correlated with the reduction of invasiveness of TSCC cells. Application of curcumin as a chemotherapeutic agent warrants further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/194799
ISSN
2015 Impact Factor: 0.832
2015 SCImago Journal Rankings: 0.382

 

DC FieldValueLanguage
dc.contributor.authorTang, WYen_US
dc.contributor.authorWong, STSen_US
dc.contributor.authorChan, JYWen_US
dc.contributor.authorWei, WIen_US
dc.date.accessioned2014-02-17T02:10:25Z-
dc.date.available2014-02-17T02:10:25Z-
dc.date.issued2011en_US
dc.identifier.citationThe 4th International Congress of Molecular Medicine, Istanbul, Turkey, 27-30 June, 2011. In in vivo, 2011, v. 25 n. 3, p. 561, abstract no. 249en_US
dc.identifier.issn0258-851X-
dc.identifier.urihttp://hdl.handle.net/10722/194799-
dc.description.abstractBACKGROUND: Curcumin is a natural polyphenol. Its anticancer effect has been σηοςν in various cancer types, including head and neck squamous cell carcinoma. Our study hypothesized that curcumin may suppress the invasiveness of tongue squamous cell carcinoma (TSCC) through the down-regulation of matrix metalloproteinase 10 (MMP10). METHODS: mRNAmicroarray analysis was performed on HN21B, in response to curcumin. Immunohistochemical staining of MMP10 was performed on a tissue array. MMP10 expression levels were verified by qRT-PCR, Western blotting and immunohistochemical staining on TSCC cell lines. The effect of curcumin on TSCC cell lines was assessed by wound healing, adhesion, migration and invasion assays. RESULTS: Microarray analysis showed that MMP10 was down-regulated by 2.36-fold in HN21B in response to curcumin. In 13 out of 20 cases (65%), the TSCC tissue showed higher MMP10 expression than the adjacent normal tissue. Curcumin treatment of TSCC cell lines resulted in down-regulation of MMP10 gene and protein expression level in a dose-dependent manner. Curcumin also suppressed adhesion, migration and invasion of TSCC cell lines. CONCLUSION: Curcumin treatment reduced MMP10 expression level in TSCC cell lines. This correlated with the reduction of invasiveness of TSCC cells. Application of curcumin as a chemotherapeutic agent warrants further investigation.-
dc.languageengen_US
dc.publisherInternational Institute of Anticancer Research. The Journal's web site is located at iiar@iiar-anticancer.org-
dc.relation.ispartofin vivoen_US
dc.subjectMedical sciences-
dc.subjectExperimental medicine, laboratory technique-
dc.titleCurcumin inhibits cancer cell migration and invasion in squamous cell carcinoma of the tongue through down-regulation of MMP10en_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, STS: thiansze@graduate.hku.hken_US
dc.identifier.emailChan, JYW: jywchan1@hku.hken_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityWong, STS=rp00478en_US
dc.identifier.authorityChan, JYW=rp01314en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros227807en_US
dc.identifier.volume25-
dc.identifier.issue3-
dc.identifier.spage561-
dc.identifier.epage561-
dc.publisher.placeGreece-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats