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Article: In-cell NMR: an emerging approach for monitoring metal-related events in living cells

TitleIn-cell NMR: an emerging approach for monitoring metal-related events in living cells
Authors
Issue Date2014
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/MT/About.asp
Citation
Metallomics, 2014, v. 6 n. 1, p. 69-76 How to Cite?
AbstractIn-cell NMR, an isotope-assisted multi-dimensional NMR technique, has been proven to be successful in the investigation of protein dynamics, folding, conformational changes induced by binding events, posttranslational modification in the complex native environments, as well as in vivo drug screening, even de novo 3D protein structure determination in living cells. This technique was initially applied to bacterial cells, and subsequently has been extended to various other cells including eukaryotic cells. In this review, we briefly summarize the methodology and application of in-cell NMR with a focus on its application in metallomics and metalloproteomics. This emerging technique is anticipated to be an excellent tool for studying metal-associated events in complex native environments of living cells.
Persistent Identifierhttp://hdl.handle.net/10722/194673
ISSN
2015 Impact Factor: 3.54
2015 SCImago Journal Rankings: 1.120
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Hen_US
dc.contributor.authorSun, Hen_US
dc.date.accessioned2014-02-17T02:02:41Z-
dc.date.available2014-02-17T02:02:41Z-
dc.date.issued2014en_US
dc.identifier.citationMetallomics, 2014, v. 6 n. 1, p. 69-76en_US
dc.identifier.issn1756-5901en_US
dc.identifier.urihttp://hdl.handle.net/10722/194673-
dc.description.abstractIn-cell NMR, an isotope-assisted multi-dimensional NMR technique, has been proven to be successful in the investigation of protein dynamics, folding, conformational changes induced by binding events, posttranslational modification in the complex native environments, as well as in vivo drug screening, even de novo 3D protein structure determination in living cells. This technique was initially applied to bacterial cells, and subsequently has been extended to various other cells including eukaryotic cells. In this review, we briefly summarize the methodology and application of in-cell NMR with a focus on its application in metallomics and metalloproteomics. This emerging technique is anticipated to be an excellent tool for studying metal-associated events in complex native environments of living cells.en_US
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/MT/About.aspen_US
dc.relation.ispartofMetallomicsen_US
dc.titleIn-cell NMR: an emerging approach for monitoring metal-related events in living cellsen_US
dc.typeArticleen_US
dc.identifier.emailLi, H: hylichem@hku.hken_US
dc.identifier.emailSun, H: hsun@hku.hken_US
dc.identifier.authoritySun, H=rp00777en_US
dc.identifier.doi10.1039/c3mt00224a-
dc.identifier.pmid24201382-
dc.identifier.scopuseid_2-s2.0-84890953655-
dc.identifier.hkuros227914en_US
dc.identifier.volume6en_US
dc.identifier.issue1en_US
dc.identifier.spage69en_US
dc.identifier.epage76en_US
dc.identifier.isiWOS:000328891100005-
dc.publisher.placeUnited Kingdomen_US

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