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Article: STAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma

TitleSTAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma
Authors
Issue Date2013
Citation
Cancer Letters, 2013, v. 330 n. 2, p. 141-149 How to Cite?
AbstractNasopharyngeal carcinoma (NPC), an endemic head and neck cancer found in Southeast Asia, is etiologically associated with the infection of an oncogenic virus, the Epstein-Barr virus (EBV). Here, we review literature findings on the potential/putative role of STAT3 signaling in its pathogenesis and discuss anti-STAT3 targeting as a therapeutic and possibly prevention strategy for NPC. Lastly, the potential involvement of STAT3 in other oncovirus-associated (e.g. the human papillomavirus) head and neck cancers have not been investigated and we hope that findings in EBV-associated NPC can prompt future investigations in these cancers, which are of increasing impact in the Western countries. © 2012 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/194494
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, Y-
dc.contributor.authorTsao, S-W-
dc.contributor.authorZeng, M-
dc.contributor.authorLui, VWY-
dc.date.accessioned2014-01-30T03:32:39Z-
dc.date.available2014-01-30T03:32:39Z-
dc.date.issued2013-
dc.identifier.citationCancer Letters, 2013, v. 330 n. 2, p. 141-149-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10722/194494-
dc.description.abstractNasopharyngeal carcinoma (NPC), an endemic head and neck cancer found in Southeast Asia, is etiologically associated with the infection of an oncogenic virus, the Epstein-Barr virus (EBV). Here, we review literature findings on the potential/putative role of STAT3 signaling in its pathogenesis and discuss anti-STAT3 targeting as a therapeutic and possibly prevention strategy for NPC. Lastly, the potential involvement of STAT3 in other oncovirus-associated (e.g. the human papillomavirus) head and neck cancers have not been investigated and we hope that findings in EBV-associated NPC can prompt future investigations in these cancers, which are of increasing impact in the Western countries. © 2012 Elsevier Ireland Ltd.-
dc.languageeng-
dc.relation.ispartofCancer Letters-
dc.titleSTAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2012.11.052-
dc.identifier.pmid23220625-
dc.identifier.scopuseid_2-s2.0-84873085220-
dc.identifier.hkuros217749-
dc.identifier.volume330-
dc.identifier.issue2-
dc.identifier.spage141-
dc.identifier.epage149-
dc.identifier.isiWOS:000315308000003-

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