File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Improving the efficiency of delivery of thrombolysis for acute stroke: A systematic review

TitleImproving the efficiency of delivery of thrombolysis for acute stroke: A systematic review
Authors
Issue Date2004
Citation
QJM - Monthly Journal of the Association of Physicians, 2004, v. 97 n. 5, p. 273-279 How to Cite?
AbstractBackground: Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is licensed for use within 3 h of acute ischaemic stroke. The less the delay to treatment, the more likely it is to be effective. Aims: To assess the effectiveness of interventions designed to overcome barriers to rapid administration of thrombolytic therapy. Design: Systematic review of previous clinical studies. Methods: We searched for studies that evaluated the effect of an intervention to reduce delays to administration of rt-PA. We searched MEDLINE, EMBASE, the trials register of the Cochrane Stroke Group, and the Cochrane Controlled Trials Register. We sought randomized and non-randomized controlled trials, before-and-after studies, interrupted time series, and observational studies. Results: We identified 10 non-randomized studies that evaluated interventions that could speed up admission to hospital and administration of rt-PA. The types of interventions included: (a) education programmes for the public to improve their knowledge about symptoms of acute stroke; (b) training programmes for paramedical staff to improve their accuracy of stroke diagnosis and hasten transport of the patient to hospital; (c) helicopter transfer of patients to hospital; (d) training programmes in acute stroke therapy for emergency department staff; and (e) re-organization of in-hospital systems to stream-line acute stroke care. Several programmes were multifaceted interventions. Discussion: We identified important areas that could be targets for interventions to improve the efficiency of delivering thrombolysis for acute stroke. Multifaceted programmes might be more likely to be successful in reducing delays to therapy. © Association of Physicians 2004; all rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/194151
ISSN
2015 Impact Factor: 2.824
2015 SCImago Journal Rankings: 0.633
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwan, J-
dc.contributor.authorHand, P-
dc.contributor.authorSandercock, P-
dc.date.accessioned2014-01-30T03:32:14Z-
dc.date.available2014-01-30T03:32:14Z-
dc.date.issued2004-
dc.identifier.citationQJM - Monthly Journal of the Association of Physicians, 2004, v. 97 n. 5, p. 273-279-
dc.identifier.issn1460-2725-
dc.identifier.urihttp://hdl.handle.net/10722/194151-
dc.description.abstractBackground: Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is licensed for use within 3 h of acute ischaemic stroke. The less the delay to treatment, the more likely it is to be effective. Aims: To assess the effectiveness of interventions designed to overcome barriers to rapid administration of thrombolytic therapy. Design: Systematic review of previous clinical studies. Methods: We searched for studies that evaluated the effect of an intervention to reduce delays to administration of rt-PA. We searched MEDLINE, EMBASE, the trials register of the Cochrane Stroke Group, and the Cochrane Controlled Trials Register. We sought randomized and non-randomized controlled trials, before-and-after studies, interrupted time series, and observational studies. Results: We identified 10 non-randomized studies that evaluated interventions that could speed up admission to hospital and administration of rt-PA. The types of interventions included: (a) education programmes for the public to improve their knowledge about symptoms of acute stroke; (b) training programmes for paramedical staff to improve their accuracy of stroke diagnosis and hasten transport of the patient to hospital; (c) helicopter transfer of patients to hospital; (d) training programmes in acute stroke therapy for emergency department staff; and (e) re-organization of in-hospital systems to stream-line acute stroke care. Several programmes were multifaceted interventions. Discussion: We identified important areas that could be targets for interventions to improve the efficiency of delivering thrombolysis for acute stroke. Multifaceted programmes might be more likely to be successful in reducing delays to therapy. © Association of Physicians 2004; all rights reserved.-
dc.languageeng-
dc.relation.ispartofQJM - Monthly Journal of the Association of Physicians-
dc.titleImproving the efficiency of delivery of thrombolysis for acute stroke: A systematic review-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/qjmed/hch054-
dc.identifier.pmid15100420-
dc.identifier.scopuseid_2-s2.0-2442646379-
dc.identifier.volume97-
dc.identifier.issue5-
dc.identifier.spage273-
dc.identifier.epage279-
dc.identifier.isiWOS:000221505000003-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats