granted patent: BROADLY CROSS-REACTIVE NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS SELECTED BY ENV-CD4-CO-RECEPTOR COMPLEXES

TitleBROADLY CROSS-REACTIVE NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS SELECTED BY ENV-CD4-CO-RECEPTOR COMPLEXES
Granted PatentUS 20070212349
Granted Date2007-09-13
Priority Date2007-05-15 US 11/748992
2001-10-16 US 09/329709P
2002-10-16 PCT/US2002033165
2004-05-05 US 10/492729
Inventors
Issue Date2007
Citation
US Patent US 20070212349. Washington, DC: US Patent and Trademark Office (USPTO), 2007 How to Cite?
AbstractThe present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention.
Persistent Identifierhttp://hdl.handle.net/10722/194058

 

DC FieldValueLanguage
dc.date.accessioned2014-01-29T05:23:45Z-
dc.date.available2014-01-29T05:23:45Z-
dc.date.issued2007-
dc.identifier.citationUS Patent US 20070212349. Washington, DC: US Patent and Trademark Office (USPTO), 2007en_US
dc.identifier.urihttp://hdl.handle.net/10722/194058-
dc.description.abstractThe present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention.en_US
dc.relation.isreferencedbyWO 2012047598 (A1) 2012-04-12en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documentsen_US
dc.titleBROADLY CROSS-REACTIVE NEUTRALIZING ANTIBODIES AGAINST HUMAN IMMUNODEFICIENCY VIRUS SELECTED BY ENV-CD4-CO-RECEPTOR COMPLEXESen_US
dc.typePatenten_US
dc.description.naturepublished_or_final_version-
dc.contributor.inventorDIMITROV DIMITER Sen_US
dc.contributor.inventorMOULARD MAXIMEen_US
dc.contributor.inventorXIAO XIADONGen_US
dc.contributor.inventorSHU YUUEIen_US
dc.contributor.inventorPHOGAT SANJAY Ken_US
dc.contributor.inventorZHANG MEI-YUNen_US
dc.contributor.inventorBURTON DENNISen_US
patents.identifier.applicationUS 11/748992en_US
patents.identifier.grantedUS 20070212349en_US
patents.description.assigneeSCRIPPS RESEARCH INST [US]en_US
patents.description.countryUnited States of Americaen_US
patents.date.granted2007-09-13en_US
patents.date.application2007-05-15en_US
patents.date.priority2007-05-15 US 11/748992en_US
patents.date.priority2001-10-16 US 09/329709Pen_US
patents.date.priority2002-10-16 PCT/US2002033165en_US
patents.date.priority2004-05-05 US 10/492729en_US
patents.description.ccusen_US
patents.relation.familyAT 481109 (T) 2010-10-15en_US
patents.relation.familyAU 2002337885 (B1) 2003-04-28en_US
patents.relation.familyCA 2463931 (A1) 2003-04-24en_US
patents.relation.familyEP 1450857 (A2) 2004-09-01en_US
patents.relation.familyUS 2004259075 (A1) 2004-12-23en_US
patents.relation.familyUS 7223844 (B2) 2007-05-29en_US
patents.relation.familyUS 7378093 (B2) 2008-05-27en_US
patents.relation.familyWO 03033666 (A2) 2003-04-24en_US
patents.description.kindA1en_US
patents.typePatent_granteden_US

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