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Article: Neuropathology of cigarette smoking

TitleNeuropathology of cigarette smoking
Authors
Issue Date2014
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00401/index.htm
Citation
Acta Neuropathologica, 2014, v. 127 n. 1, p. 53-69 How to Cite?
Abstractt is well established that cigarette smoking is hazardous to health and is a risk factor for many chronic diseases. However, its impact on the brain, whether it be from prenatal exposure to maternal cigarette smoking, cerebrovascular disease, Alzheimer’s disease (AD) or Parkinson’s disease, is still not very clear. Neuroimaging and neuropathological investigations suggest that there are heterogeneous effects of cigarette smoking on the brain. On the one hand, it is quite clear that cigarette smoking causes damage to endothelial cells, resulting in increased risk of cerebrovascular disease. On the other hand, it seems to be associated with different Alzheimer’s pathologies in post-mortem brains and experimental models, despite the fact that epidemiological studies clearly indicate a positive correlation between cigarette smoking and increased risk for AD. Interestingly, cigarette smoking appears to be associated with reduced Parkinson’s pathology in post-mortem brains. However, although nicotine in cigarettes may have some neuroprotective actions, the effects of all the other toxic compounds in cigarettes cannot be ignored. It is, therefore, our aim to summarize what is known about the neuropathology of cigarette smoking and, in particular, its implications for neurodegenerative diseases.
Persistent Identifierhttp://hdl.handle.net/10722/193857
ISSN
2015 Impact Factor: 11.36
2015 SCImago Journal Rankings: 6.610
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChang, RCCen_US
dc.contributor.authorHo, YSen_US
dc.contributor.authorWong, Sen_US
dc.contributor.authorGentleman, SMen_US
dc.contributor.authorNg, HKen_US
dc.date.accessioned2014-01-28T06:28:21Z-
dc.date.available2014-01-28T06:28:21Z-
dc.date.issued2014en_US
dc.identifier.citationActa Neuropathologica, 2014, v. 127 n. 1, p. 53-69en_US
dc.identifier.issn0001-6322-
dc.identifier.urihttp://hdl.handle.net/10722/193857-
dc.description.abstractt is well established that cigarette smoking is hazardous to health and is a risk factor for many chronic diseases. However, its impact on the brain, whether it be from prenatal exposure to maternal cigarette smoking, cerebrovascular disease, Alzheimer’s disease (AD) or Parkinson’s disease, is still not very clear. Neuroimaging and neuropathological investigations suggest that there are heterogeneous effects of cigarette smoking on the brain. On the one hand, it is quite clear that cigarette smoking causes damage to endothelial cells, resulting in increased risk of cerebrovascular disease. On the other hand, it seems to be associated with different Alzheimer’s pathologies in post-mortem brains and experimental models, despite the fact that epidemiological studies clearly indicate a positive correlation between cigarette smoking and increased risk for AD. Interestingly, cigarette smoking appears to be associated with reduced Parkinson’s pathology in post-mortem brains. However, although nicotine in cigarettes may have some neuroprotective actions, the effects of all the other toxic compounds in cigarettes cannot be ignored. It is, therefore, our aim to summarize what is known about the neuropathology of cigarette smoking and, in particular, its implications for neurodegenerative diseases.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00401/index.htmen_US
dc.relation.ispartofActa Neuropathologicaen_US
dc.titleNeuropathology of cigarette smokingen_US
dc.typeArticleen_US
dc.identifier.emailChang, RCC: rccchang@hku.hken_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.identifier.doi10.1007/s00401-013-1210-x-
dc.identifier.pmid24240736-
dc.identifier.hkuros227386en_US
dc.identifier.volume127en_US
dc.identifier.issue1-
dc.identifier.spage53en_US
dc.identifier.epage69en_US
dc.identifier.isiWOS:000329225300004-
dc.publisher.placeGermanyen_US

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