The immunogenicity of hepatitis A vaccine in Chinese children

Abstract

Objective Data on immunogenicity of hepatitis A vaccines (including inactivated and live attenuated vaccine) have been reviewed using a systematic approach in Chinese children. Our mission is to provide a comprehensive review of evidence that whether vaccine types, booster, dosage and age could affect immunogenicity.

Methodology A systematic literature review was conducted including all studies reporting on immunogenicity of hepatitis A vaccine. The outcomes considered were hepatitis A Geometric Mean Concentration (GMC) and sero-conversion proportions measured by anti-HAV antibodies after immunization.

Results 20 studies were identified from PubMed and Google Scholar according to searching concept. 7 manuscripts met our inclusion criteria. The Sero-conversion proportions of inactivated vaccine (Havrix and Healive)and live attenuated vaccine(H2) were close to 100% after 4-week injection, and GMC of them were 67.2mIU/ml, 71.3mIU/ml and 46.8mIU/ml respectively. Another live attenuated vaccine (LA-1) has been reported no significant differences fromH2 in terms of the Sero-conversion proportions and GMC. Booster demonstrated a stronger response both in inactivated and live attenuated vaccines. In terms of dosage, although more dosage could offer higher GMC, adequate dosage was recommended. In addition, the GMC of less dosage one was significantly lower than that of more dosage after 24 months of first injection.

Conclusion Available data indicate that immunogenicity of inactivated and live attenuated Hepatitis A is extremely similar, and both could provide protection for Chinese children. Using booster of inactivated and live attenuated hepatitis A vaccine can increase the immunogenicity.