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Conference Paper: Plasma Fibrinogen Level as a Predictor of Cardiovascular Diseases, Independent of Diabetes, in a Population-Based 16-Year Prospective Study in Hong Kong

TitlePlasma Fibrinogen Level as a Predictor of Cardiovascular Diseases, Independent of Diabetes, in a Population-Based 16-Year Prospective Study in Hong Kong
Authors
Issue Date2013
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
The 73rd Scientific Sessions of the American Diabetes Association (ADA), Chicago, Illinois, USA, 21-25 June 2013. In Diabetes, 2013, v. 62 n. Suppl. 1, p. A370, abstract no. 1417-P How to Cite?
AbstractRecent evidence from prospective studies in the United States and Europe suggest plasma fibrinogen level is useful for prediction of cardiovascular risk in addition to conventional risk factors. As one of the acute-phase reactant proteins, fibrinogen increases in response to the inflammatory process of atherosclerosis. Baseline data of the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS), commenced in 1995-6, showed close positive relationship between circulating fibrinogen levels and diabetes, a major cardiovascular risk factor. In this study, we examined whether plasma fibrinogen was predictive of incident cardiovascular diseases (CVD) over 15.9 years (IQR 15.5 [[unable to display character: –]] 16.5) in the CRISPS cohort, and whether the prediction was dependent on its association with diabetes. Of a total of 2774 subjects, 374 had confirmed incident CVD. In addition to male sex and age, baseline body mass index (BMI), waist circumference (WC), fasting glucose, 2-hour glucose after oral glucose tolerance test, insulin resistance index HOMA-IR, systolic and diastolic BP, triglycerides (TGs), high-density lipoprotein, the presence of diabetes, hypertension, dyslipidaemia, and fibrinogen level were all predictive of incident CVD over 15.9 years (all p<0.001). Fibrinogen level correlated positively with fasting glucose, HOMA-IR, BMI, WC, systolic and diastolic BP, and TGs after sex and age adjustment (all p<0.001).On multivariate analysis, baseline age, WC, diabetes, hypertension, and fibrinogen level were independent risk factors (p≤0.001) for incident CVD. In conclusion, the findings from this 16-year prospective study confirmed plasma fibrinogen level as a strong predictor of CVD, independent of diabetes, in community-based Chinese adults.
DescriptionGeneral Poster Session 2: Epidemiology—Cardiovascular Disease
Persistent Identifierhttp://hdl.handle.net/10722/193382
ISSN
2015 Impact Factor: 8.784
2015 SCImago Journal Rankings: 5.185

 

DC FieldValueLanguage
dc.contributor.authorHui, YLEen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorChow, WSen_US
dc.contributor.authorYeung, CYen_US
dc.contributor.authorWoo, YCen_US
dc.contributor.authorFong, HYen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorTse, HFen_US
dc.contributor.authorCheung, BMYen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2013-12-20T03:03:46Z-
dc.date.available2013-12-20T03:03:46Z-
dc.date.issued2013en_US
dc.identifier.citationThe 73rd Scientific Sessions of the American Diabetes Association (ADA), Chicago, Illinois, USA, 21-25 June 2013. In Diabetes, 2013, v. 62 n. Suppl. 1, p. A370, abstract no. 1417-Pen_US
dc.identifier.issn0012-1797-
dc.identifier.urihttp://hdl.handle.net/10722/193382-
dc.descriptionGeneral Poster Session 2: Epidemiology—Cardiovascular Disease-
dc.description.abstractRecent evidence from prospective studies in the United States and Europe suggest plasma fibrinogen level is useful for prediction of cardiovascular risk in addition to conventional risk factors. As one of the acute-phase reactant proteins, fibrinogen increases in response to the inflammatory process of atherosclerosis. Baseline data of the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS), commenced in 1995-6, showed close positive relationship between circulating fibrinogen levels and diabetes, a major cardiovascular risk factor. In this study, we examined whether plasma fibrinogen was predictive of incident cardiovascular diseases (CVD) over 15.9 years (IQR 15.5 [[unable to display character: –]] 16.5) in the CRISPS cohort, and whether the prediction was dependent on its association with diabetes. Of a total of 2774 subjects, 374 had confirmed incident CVD. In addition to male sex and age, baseline body mass index (BMI), waist circumference (WC), fasting glucose, 2-hour glucose after oral glucose tolerance test, insulin resistance index HOMA-IR, systolic and diastolic BP, triglycerides (TGs), high-density lipoprotein, the presence of diabetes, hypertension, dyslipidaemia, and fibrinogen level were all predictive of incident CVD over 15.9 years (all p<0.001). Fibrinogen level correlated positively with fasting glucose, HOMA-IR, BMI, WC, systolic and diastolic BP, and TGs after sex and age adjustment (all p<0.001).On multivariate analysis, baseline age, WC, diabetes, hypertension, and fibrinogen level were independent risk factors (p≤0.001) for incident CVD. In conclusion, the findings from this 16-year prospective study confirmed plasma fibrinogen level as a strong predictor of CVD, independent of diabetes, in community-based Chinese adults.-
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/-
dc.relation.ispartofDiabetesen_US
dc.titlePlasma Fibrinogen Level as a Predictor of Cardiovascular Diseases, Independent of Diabetes, in a Population-Based 16-Year Prospective Study in Hong Kongen_US
dc.typeConference_Paperen_US
dc.identifier.emailHui, YLE: eylhui@hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailChow, WS: chowws01@hkucc.hku.hken_US
dc.identifier.emailYeung, CY: ycy167@hku.hken_US
dc.identifier.emailWoo, YC: wooyucho@hku.hken_US
dc.identifier.emailFong, HY: kalofong@hku.hken_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_US
dc.identifier.emailCheung, BMY: mycheung@hku.hken_US
dc.identifier.emailLam, KSL: ksllam@hku.hken_US
dc.identifier.authorityHui, YLE=rp01660en_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.authorityCheung, BMY=rp01321en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.2337/db13-1395-1677-
dc.identifier.hkuros226956en_US
dc.identifier.hkuros223868-
dc.identifier.volume62-
dc.identifier.issueSuppl. 1-
dc.identifier.spageA370, abstract no. 1417-
dc.identifier.epageA370, abstract no. 1417-
dc.publisher.placeUnited States-

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