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Article: Effect of diffusion time on liver DWI: An experimental study of normal and fibrotic livers

TitleEffect of diffusion time on liver DWI: An experimental study of normal and fibrotic livers
Authors
KeywordsB-value
Diffusion time
Liver fibrosis
Rat
Restricted diffusion
Issue Date2014
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance in Medicine, 2014, v. 72 n. 5, p. 1389–1396 How to Cite?
AbstractPurpose: To investigate whether diffusion time (Δ) affects the diffusion measurements in liver and their sensitivity in detecting fibrosis. Methods: Liver fibrosis was induced in Sprague-Dawley rats (n = 12) by carbon tetrachloride (CCl4) injections. Diffusionweighted MRI was performed longitudinally during 8-week CCl4 administration at 7 Tesla (T) using single-shot stimulatedecho EPI with five b-values (0 to 1000 s/mm2) and three Ds. Apparent diffusion coefficient (ADC) and true diffusion coefficient (Dtrue) were calculated by using all five b-values and large b-values, respectively. Results: ADC and Dtrue decreased with D for both normal and fibrotic liver at each time point. ADC and Dtrue also generally decreased with the time after CCl4 insult. The reductions in Dtrue between 2-week and 4-week CCl4 insult were larger than the ADC reductions at all Ds. At each time point, Dtrue measured with long Δ (200 ms) detected the largest changes among the 3 Δs examined. Histology revealed gradual collagen deposition and presence of intracellular fat vacuoles after CCl4 insult. Conclusion: Our results demonstrated the Δ dependent diffusion measurements, indicating restricted diffusion in both normal and fibrotic liver. Dtrue measured with long Δ acted as a more sensitive index of the pathological alterations in liver microstructure during fibrogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/193183
ISSN
2017 Impact Factor: 4.082
2015 SCImago Journal Rankings: 2.197
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, IY-
dc.contributor.authorGao, DS-
dc.contributor.authorChow, AMK-
dc.contributor.authorFan, S-
dc.contributor.authorCheung, MMH-
dc.contributor.authorLing, C-
dc.contributor.authorLiu, X-
dc.contributor.authorCao, P-
dc.contributor.authorGuo, H-
dc.contributor.authorMan, K-
dc.contributor.authorWu, EX-
dc.date.accessioned2013-12-20T02:30:10Z-
dc.date.available2013-12-20T02:30:10Z-
dc.date.issued2014-
dc.identifier.citationMagnetic Resonance in Medicine, 2014, v. 72 n. 5, p. 1389–1396-
dc.identifier.issn0740-3194-
dc.identifier.urihttp://hdl.handle.net/10722/193183-
dc.description.abstractPurpose: To investigate whether diffusion time (Δ) affects the diffusion measurements in liver and their sensitivity in detecting fibrosis. Methods: Liver fibrosis was induced in Sprague-Dawley rats (n = 12) by carbon tetrachloride (CCl4) injections. Diffusionweighted MRI was performed longitudinally during 8-week CCl4 administration at 7 Tesla (T) using single-shot stimulatedecho EPI with five b-values (0 to 1000 s/mm2) and three Ds. Apparent diffusion coefficient (ADC) and true diffusion coefficient (Dtrue) were calculated by using all five b-values and large b-values, respectively. Results: ADC and Dtrue decreased with D for both normal and fibrotic liver at each time point. ADC and Dtrue also generally decreased with the time after CCl4 insult. The reductions in Dtrue between 2-week and 4-week CCl4 insult were larger than the ADC reductions at all Ds. At each time point, Dtrue measured with long Δ (200 ms) detected the largest changes among the 3 Δs examined. Histology revealed gradual collagen deposition and presence of intracellular fat vacuoles after CCl4 insult. Conclusion: Our results demonstrated the Δ dependent diffusion measurements, indicating restricted diffusion in both normal and fibrotic liver. Dtrue measured with long Δ acted as a more sensitive index of the pathological alterations in liver microstructure during fibrogenesis.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/-
dc.relation.ispartofMagnetic Resonance in Medicine-
dc.subjectB-value-
dc.subjectDiffusion time-
dc.subjectLiver fibrosis-
dc.subjectRat-
dc.subjectRestricted diffusion-
dc.titleEffect of diffusion time on liver DWI: An experimental study of normal and fibrotic livers-
dc.typeArticle-
dc.identifier.emailZhou, IY: iriszhou@eee.hku.hk-
dc.identifier.emailGao, DS: issgao@hku.hk-
dc.identifier.emailChow, AMK: aprilcmk@hkusua.hku.hk-
dc.identifier.emailFan, S: fanshj08@hkucc.hku.hk-
dc.identifier.emailCheung, MMH: thew@hku.hk-
dc.identifier.emailLing, C: lingccl@hku.hk-
dc.identifier.emailLiu, X: liuxb301@hku.hk-
dc.identifier.emailCao, P: caopeng1@hku.hk-
dc.identifier.emailMan, K: kwanman@hku.hk-
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hk-
dc.identifier.authorityZhou, IY=rp01739-
dc.identifier.authorityMan, K=rp00417-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mrm.25035-
dc.identifier.pmid24258877-
dc.identifier.scopuseid_2-s2.0-84907953503-
dc.identifier.hkuros227172-
dc.identifier.volume72-
dc.identifier.issue5-
dc.identifier.spage1389–1396-
dc.identifier.epage1389–1396-
dc.identifier.isiWOS:000343873900021-
dc.publisher.placeUnited States-

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