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Article: Solid phase microextraction fills the gap in tissue sampling protocols

TitleSolid phase microextraction fills the gap in tissue sampling protocols
Authors
Issue Date2013
Citation
Analytica Chimica Acta, 2013, v. 803, p. 75-81 How to Cite?
AbstractMetabolomics and biomarkers discovery are an integral part of bioanalysis. However, untargeted tissue analysis remains as the bottleneck of such studies due to the invasiveness of sample collection, as well as the laborious and time-consuming sample preparation protocols. In the current study, technology integrating in vivo sampling, sample preparation and global extraction of metabolites - solid phase microextraction was presented and evaluated during liver and lung transplantation in pig model. Sampling approaches, including selection of the probe, transportation, storage conditions and analyte coverage were discussed. The applicability of the method for metabolomics studies was demonstrated during lung transplantation experiments. © 2013 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/192692
ISSN
2015 Impact Factor: 4.712
2015 SCImago Journal Rankings: 1.548
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBojko, Ben_US
dc.contributor.authorGorynski, Ken_US
dc.contributor.authorGomez-Rios, GAen_US
dc.contributor.authorKnaak, JMen_US
dc.contributor.authorMachuca, Ten_US
dc.contributor.authorSpetzler, VNen_US
dc.contributor.authorCudjoe, Een_US
dc.contributor.authorHsin, Men_US
dc.contributor.authorCypel, Men_US
dc.contributor.authorSelzner, Men_US
dc.contributor.authorLiu, Men_US
dc.contributor.authorKeshavjee, Sen_US
dc.contributor.authorPawliszyn, Jen_US
dc.date.accessioned2013-11-20T04:55:23Z-
dc.date.available2013-11-20T04:55:23Z-
dc.date.issued2013en_US
dc.identifier.citationAnalytica Chimica Acta, 2013, v. 803, p. 75-81en_US
dc.identifier.issn0003-2670en_US
dc.identifier.urihttp://hdl.handle.net/10722/192692-
dc.description.abstractMetabolomics and biomarkers discovery are an integral part of bioanalysis. However, untargeted tissue analysis remains as the bottleneck of such studies due to the invasiveness of sample collection, as well as the laborious and time-consuming sample preparation protocols. In the current study, technology integrating in vivo sampling, sample preparation and global extraction of metabolites - solid phase microextraction was presented and evaluated during liver and lung transplantation in pig model. Sampling approaches, including selection of the probe, transportation, storage conditions and analyte coverage were discussed. The applicability of the method for metabolomics studies was demonstrated during lung transplantation experiments. © 2013 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.relation.ispartofAnalytica Chimica Actaen_US
dc.titleSolid phase microextraction fills the gap in tissue sampling protocolsen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.aca.2013.08.031en_US
dc.identifier.pmid24216199-
dc.identifier.scopuseid_2-s2.0-84887408490en_US
dc.identifier.hkuros239181-
dc.identifier.isiWOS:000326684000008-

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