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Conference Paper: Effect of silver-diamine-fluoride on dentine demineralisation and collagen degradation

TitleEffect of silver-diamine-fluoride on dentine demineralisation and collagen degradation
Authors
KeywordsCaries
Cariology
Demineralization/Remineralization
Dentin and Fluoride
Issue Date2013
PublisherSage Publications, Inc. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
The 2nd Meeting of the International Association of Dental Research - Asia Pacific Region (IADR-APR), Bangkok, Thailand, 21-23 August 2013. In Journal of Dental Research, 2013, v. 92 n. Special Issue B: abstract no. 735 How to Cite?
AbstractObjective: To investigate the inhibitory effects of 38% silver diamine fluoride (SDF) on demineralised dentine. Methods: Human dentine blocks were demineralised and allocated to four groups: SF, F, S and W. The blocks in group SF received a topical application of 38% SDF solution (253,900 ppm Ag, 44,800 ppm F), group F received a 10% sodium fluoride solution (44,800 ppm F), group S received a 42% silver nitrate solution (253,900 ppm Ag) and group W received deionised water (control). They were subjected to pH cycling using demineralisation solution (pH 5) and remineralisation solution (pH 7) for 8 days. The surface morphology, crystal characteristics, lesion depth and collagen matrix degradation of the specimens were investigated by scanning electron microscopy (SEM), x-ray diffraction (XRD), micro-CT, and spectrophotometry with a hydroxyproline assay. Results: The surface morphology under SEM showed evident demineralisation with exposed collagen in groups S and W, but not in group SF. Clusters of granular spherical grains were observed in the cross-sections of the specimens in groups SF and F. XRD revealed precipitates of silver chloride in groups SF and S. The mean lesion depth (±SD) in groups SF, F, S and W were 182±32 µm, 204±26 µm, 259±42 µm and 265±40 µm, respectively (SDF, F
DescriptionConference Theme: We are the Future
Oral Presentation
Session 29: O20
Persistent Identifierhttp://hdl.handle.net/10722/192587
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorMei, Len_US
dc.contributor.authorIto, Len_US
dc.contributor.authorCao, Yen_US
dc.contributor.authorLi, Qen_US
dc.contributor.authorLo, ECMen_US
dc.contributor.authorChu, CHen_US
dc.date.accessioned2013-11-18T05:06:51Z-
dc.date.available2013-11-18T05:06:51Z-
dc.date.issued2013en_US
dc.identifier.citationThe 2nd Meeting of the International Association of Dental Research - Asia Pacific Region (IADR-APR), Bangkok, Thailand, 21-23 August 2013. In Journal of Dental Research, 2013, v. 92 n. Special Issue B: abstract no. 735en_US
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/192587-
dc.descriptionConference Theme: We are the Future-
dc.descriptionOral Presentation-
dc.descriptionSession 29: O20-
dc.description.abstractObjective: To investigate the inhibitory effects of 38% silver diamine fluoride (SDF) on demineralised dentine. Methods: Human dentine blocks were demineralised and allocated to four groups: SF, F, S and W. The blocks in group SF received a topical application of 38% SDF solution (253,900 ppm Ag, 44,800 ppm F), group F received a 10% sodium fluoride solution (44,800 ppm F), group S received a 42% silver nitrate solution (253,900 ppm Ag) and group W received deionised water (control). They were subjected to pH cycling using demineralisation solution (pH 5) and remineralisation solution (pH 7) for 8 days. The surface morphology, crystal characteristics, lesion depth and collagen matrix degradation of the specimens were investigated by scanning electron microscopy (SEM), x-ray diffraction (XRD), micro-CT, and spectrophotometry with a hydroxyproline assay. Results: The surface morphology under SEM showed evident demineralisation with exposed collagen in groups S and W, but not in group SF. Clusters of granular spherical grains were observed in the cross-sections of the specimens in groups SF and F. XRD revealed precipitates of silver chloride in groups SF and S. The mean lesion depth (±SD) in groups SF, F, S and W were 182±32 µm, 204±26 µm, 259±42 µm and 265±40 µm, respectively (SDF, F<S, W; p<0.01). Groups SF and S had significantly less hydroxyproline liberated from the dentine matrix than groups F and W (p<0.01). Conclusion: Topical application of 38% SDF solution can inhibit demineralisation and preserve collagen from degradation in demineralised dentine.-
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925-
dc.relation.ispartofJournal of Dental Researchen_US
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc.-
dc.subjectCaries-
dc.subjectCariology-
dc.subjectDemineralization/Remineralization-
dc.subjectDentin and Fluoride-
dc.titleEffect of silver-diamine-fluoride on dentine demineralisation and collagen degradationen_US
dc.typeConference_Paperen_US
dc.identifier.emailMei, L: mei1123@hku.hken_US
dc.identifier.emailLo, ECM: hrdplcm@hkucc.hku.hken_US
dc.identifier.emailChu, CH: chchu@hku.hken_US
dc.identifier.authorityMei, L=rp01840en_US
dc.identifier.authorityLo, ECM=rp00015en_US
dc.identifier.authorityChu, CH=rp00022en_US
dc.identifier.hkuros226817en_US
dc.identifier.hkuros226770-
dc.identifier.volume92en_US
dc.identifier.issueSpecial Issue B: abstract no. 735en_US
dc.publisher.placeUnited States-

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