File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Stroke assessment with diffusional kurtosis imaging

TitleStroke assessment with diffusional kurtosis imaging
Authors
Issue Date2012
Citation
Stroke, 2012, v. 43 n. 11, p. 2968-2973 How to Cite?
AbstractBackground and Purpose-Despite being the gold standard technique for stroke assessment, conventional diffusion MRI provides only partial information about tissue microstructure. Diffusional kurtosis imaging is an advanced diffusion MRI method that yields, in addition to conventional diffusion information, the diffusional kurtosis, which may help improve characterization of tissue microstructure. In particular, this additional information permits the description of white matter (WM) in terms of WM-specific diffusion metrics. The goal of this study is to elucidate possible biophysical mechanisms underlying ischemia using these new WM metrics. Methods-We performed a retrospective review of clinical and diffusional kurtosis imaging data of 44 patients with acute/subacute ischemic stroke. Patients with a history of brain neoplasm or intracranial hemorrhages were excluded from this study. Region of interest analysis was performed to measure percent change of diffusion metrics in ischemic WM lesions compared with the contralateral hemisphere. Results-Kurtosis maps exhibit distinct ischemic lesion heterogeneity that is not apparent on apparent diffusion coefficient maps. Kurtosis metrics also have significantly higher absolute percent change than complementary conventional diffusion metrics. Our WM metrics reveal an increase in axonal density and a larger decrease in the intra-axonal (Da) compared with extra-axonal diffusion microenvironment of the ischemic WM lesion. Conclusions-The well-known decrease in the apparent diffusion coefficient of WM after ischemia is found to be mainly driven by a significant drop in the intra-axonal diffusion microenvironment. Our results suggest that ischemia preferentially alters intra-axonal environment, consistent with a proposed mechanism of focal enlargement of axons known as axonal swelling or beading. © 2012 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/192106
ISSN
2015 Impact Factor: 5.787
2015 SCImago Journal Rankings: 3.671
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHui, ESen_US
dc.contributor.authorFieremans, Een_US
dc.contributor.authorJensen, JHen_US
dc.contributor.authorTabesh, Aen_US
dc.contributor.authorFeng, Wen_US
dc.contributor.authorBonilha, Len_US
dc.contributor.authorSpampinato, MVen_US
dc.contributor.authorAdams, Ren_US
dc.contributor.authorHelpern, JAen_US
dc.date.accessioned2013-10-23T09:25:34Z-
dc.date.available2013-10-23T09:25:34Z-
dc.date.issued2012en_US
dc.identifier.citationStroke, 2012, v. 43 n. 11, p. 2968-2973en_US
dc.identifier.issn0039-2499en_US
dc.identifier.urihttp://hdl.handle.net/10722/192106-
dc.description.abstractBackground and Purpose-Despite being the gold standard technique for stroke assessment, conventional diffusion MRI provides only partial information about tissue microstructure. Diffusional kurtosis imaging is an advanced diffusion MRI method that yields, in addition to conventional diffusion information, the diffusional kurtosis, which may help improve characterization of tissue microstructure. In particular, this additional information permits the description of white matter (WM) in terms of WM-specific diffusion metrics. The goal of this study is to elucidate possible biophysical mechanisms underlying ischemia using these new WM metrics. Methods-We performed a retrospective review of clinical and diffusional kurtosis imaging data of 44 patients with acute/subacute ischemic stroke. Patients with a history of brain neoplasm or intracranial hemorrhages were excluded from this study. Region of interest analysis was performed to measure percent change of diffusion metrics in ischemic WM lesions compared with the contralateral hemisphere. Results-Kurtosis maps exhibit distinct ischemic lesion heterogeneity that is not apparent on apparent diffusion coefficient maps. Kurtosis metrics also have significantly higher absolute percent change than complementary conventional diffusion metrics. Our WM metrics reveal an increase in axonal density and a larger decrease in the intra-axonal (Da) compared with extra-axonal diffusion microenvironment of the ischemic WM lesion. Conclusions-The well-known decrease in the apparent diffusion coefficient of WM after ischemia is found to be mainly driven by a significant drop in the intra-axonal diffusion microenvironment. Our results suggest that ischemia preferentially alters intra-axonal environment, consistent with a proposed mechanism of focal enlargement of axons known as axonal swelling or beading. © 2012 American Heart Association, Inc.-
dc.languageengen_US
dc.relation.ispartofStrokeen_US
dc.subject.meshDiffusion Magnetic Resonance Imaging-
dc.subject.meshImage Interpretation-
dc.subject.meshComputer-Assisted-
dc.subject.meshPilot Projects-
dc.subject.meshRetrospective Studies-
dc.subject.meshStroke-
dc.titleStroke assessment with diffusional kurtosis imagingen_US
dc.typeArticleen_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1161/STROKEAHA.112.657742en_US
dc.identifier.pmid22933581-
dc.identifier.pmcidPMC3479373-
dc.identifier.scopuseid_2-s2.0-84868196785en_US
dc.identifier.volume43en_US
dc.identifier.issue11en_US
dc.identifier.spage2968en_US
dc.identifier.epage2973en_US
dc.identifier.isiWOS:000310432800284-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats