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Article: Bacteria in sputum of stable severe asthma and increased airway wall thickness

TitleBacteria in sputum of stable severe asthma and increased airway wall thickness
Authors
Issue Date2012
PublisherBioMed Central Ltd. The Journal's web site is located at http://respiratory-research.com/
Citation
Respiratory Research, 2012, v. 13 n. 1, p. Article no. 35 How to Cite?
AbstractBACKGROUND: Patients with chronic asthma have thicker intrapulmonary airways measured on high resolution computed tomography (HRCT). We determined whether the presence of lower airway bacteria was associated with increased airway wall thickness. METHODS: In 56 patients with stable severe asthma, sputum specimens obtained either spontaneously or after induction with hypertonic saline were cultured for bacteria and thoracic HRCT scans obtained. Wall thickness (WT) and area (WA) expressed as a ratio of airway diameter (D) and total area, respectively, were measured at five levels. RESULTS: Positive bacterial cultures were obtained in 29 patients, with H. influenzae, P. aeruginosa and S. aureus being the commonest strains. Logistic regression analysis showed that this was associated with the duration of asthma and the exacerbations during the past year. In airways > 2 mm, there was no significant difference in WA (67.5 +/- 5.4 vs 66.4 +/- 5.4) and WT/D (21.6 +/- 2.7 vs 21.3 +/- 2.4) between the culture negative versus positive groups. Similarly, in airways (
Persistent Identifierhttp://hdl.handle.net/10722/192088
ISSN
2010 Impact Factor: 2.859
2015 SCImago Journal Rankings: 1.601
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Q-
dc.contributor.authorIlling, R-
dc.contributor.authorHui, CK-
dc.contributor.authorDowney, K-
dc.contributor.authorCarr, D-
dc.contributor.authorStearn, M-
dc.contributor.authorAlshafi, K-
dc.contributor.authorMenzies-Gow, A-
dc.contributor.authorZhong, N-
dc.contributor.authorChung, KF-
dc.date.accessioned2013-10-18T08:50:00Z-
dc.date.available2013-10-18T08:50:00Z-
dc.date.issued2012-
dc.identifier.citationRespiratory Research, 2012, v. 13 n. 1, p. Article no. 35-
dc.identifier.issn1465-9921-
dc.identifier.urihttp://hdl.handle.net/10722/192088-
dc.description.abstractBACKGROUND: Patients with chronic asthma have thicker intrapulmonary airways measured on high resolution computed tomography (HRCT). We determined whether the presence of lower airway bacteria was associated with increased airway wall thickness. METHODS: In 56 patients with stable severe asthma, sputum specimens obtained either spontaneously or after induction with hypertonic saline were cultured for bacteria and thoracic HRCT scans obtained. Wall thickness (WT) and area (WA) expressed as a ratio of airway diameter (D) and total area, respectively, were measured at five levels. RESULTS: Positive bacterial cultures were obtained in 29 patients, with H. influenzae, P. aeruginosa and S. aureus being the commonest strains. Logistic regression analysis showed that this was associated with the duration of asthma and the exacerbations during the past year. In airways > 2 mm, there was no significant difference in WA (67.5 +/- 5.4 vs 66.4 +/- 5.4) and WT/D (21.6 +/- 2.7 vs 21.3 +/- 2.4) between the culture negative versus positive groups. Similarly, in airways (</= 2 mm), there were no significant differences in these parameters. The ratio of radicalwall area to Pi was negatively correlated with FEV1% predicted (p < 0.05). CONCLUSIONS: Bacterial colonization of the lower airways is common in patients with chronic severe asthma and is linked to the duration of asthma and having had exacerbations in the past year, but not with an increase in airway wall thickness.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://respiratory-research.com/-
dc.relation.ispartofRespiratory Research-
dc.rightsRespiratory Research. Copyright © BioMed Central Ltd.-
dc.subject.meshAirway Remodeling-
dc.subject.meshAsthma - microbiology - radiography-
dc.subject.meshHaemophilus influenzae - isolation and purification-
dc.subject.meshPseudomonas aeruginosa - isolation and purification-
dc.subject.meshSeverity of Illness Index-
dc.titleBacteria in sputum of stable severe asthma and increased airway wall thicknessen_US
dc.typeArticleen_US
dc.identifier.emailHui, CK: chris.hui@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1186/1465-9921-13-35-
dc.identifier.pmid22513083-
dc.identifier.pmcidPMC3351013-
dc.identifier.scopuseid_2-s2.0-84859793554-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.spageArticle no. 35-
dc.identifier.epageArticle no. 35-
dc.identifier.isiWOS:000304059600001-
dc.publisher.placeUnited Kingdom-

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