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Article: Classical and follicular variant of papillary thyroid carcinoma: A comparative study on clinicopathologic features and long-term outcome

TitleClassical and follicular variant of papillary thyroid carcinoma: A comparative study on clinicopathologic features and long-term outcome
Authors
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal of Surgery, 2006, v. 30 n. 5, p. 752-758 How to Cite?
AbstractINTRODUCTION: The follicular variant of papillary thyroid carcinoma (FVPTC) is the most common histologic subtype of papillary thyroid carcinoma (PTC). However, it is still controversial whether FVPTC should behave differently from classical PTC (CPTC). The present study aimed at evaluating any potential difference in clinicopathologic features and long-term outcome of FVPTC as compared with CPTC. PATIENTS AND METHODS: Of 568 patients with PTC managed from 1973 to 2004, 308 were shown to have CPTC (54.2%) and 67 (11.8%) FVPTC after histologic review. The mean (+/- SD) follow-up period was 11.3 (+/- 8.9) years. The two groups were compared in terms of clinicopathological features, treatment received, and outcome regarding recurrence and disease-specific survival. RESULTS: There was no difference in age and gender ratio between the CPTC and FVPTC patients. Both groups had similar tumor characteristics in terms of tumor size, presence of multifocality, capsular invasion, lymphovascular permeation, and perineural infiltration. However, FVPTC patients had significantly fewer histologically confirmed cervical lymph node metastases (P = 0.027) and extrathyroidal involvement (P = 0.005). The proportion of bilateral resection, adjuvant radioactive iodine, and lymph node dissection did not differ significantly between the two groups. The FVPTC patients had a more favorable tumor risk by DeGroot classification (P = 0.003) and MACIS (Metastasis, Age, Completeness of excision, Invasiveness, and Size) score (P = 0.026). The 10- and 15-year actuarial disease-specific survivals did not differ significantly between FVPTC and CPTC patients (96.2% versus 90.7% and 96.2% versus 89.1%, respectively). CONCLUSIONS: Although patients with FVPTC had more favorable clinicopathologic features and a better tumor risk group profile, their long-term outcome was similar to that of CPTC patients.
Persistent Identifierhttp://hdl.handle.net/10722/192075
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, BH-
dc.contributor.authorLo, CY-
dc.contributor.authorChan, WF-
dc.contributor.authorLam, AKY-
dc.contributor.authorWan, KY-
dc.date.accessioned2013-10-17T02:29:40Z-
dc.date.available2013-10-17T02:29:40Z-
dc.date.issued2006-
dc.identifier.citationWorld Journal of Surgery, 2006, v. 30 n. 5, p. 752-758-
dc.identifier.issn0364-2313-
dc.identifier.urihttp://hdl.handle.net/10722/192075-
dc.description.abstractINTRODUCTION: The follicular variant of papillary thyroid carcinoma (FVPTC) is the most common histologic subtype of papillary thyroid carcinoma (PTC). However, it is still controversial whether FVPTC should behave differently from classical PTC (CPTC). The present study aimed at evaluating any potential difference in clinicopathologic features and long-term outcome of FVPTC as compared with CPTC. PATIENTS AND METHODS: Of 568 patients with PTC managed from 1973 to 2004, 308 were shown to have CPTC (54.2%) and 67 (11.8%) FVPTC after histologic review. The mean (+/- SD) follow-up period was 11.3 (+/- 8.9) years. The two groups were compared in terms of clinicopathological features, treatment received, and outcome regarding recurrence and disease-specific survival. RESULTS: There was no difference in age and gender ratio between the CPTC and FVPTC patients. Both groups had similar tumor characteristics in terms of tumor size, presence of multifocality, capsular invasion, lymphovascular permeation, and perineural infiltration. However, FVPTC patients had significantly fewer histologically confirmed cervical lymph node metastases (P = 0.027) and extrathyroidal involvement (P = 0.005). The proportion of bilateral resection, adjuvant radioactive iodine, and lymph node dissection did not differ significantly between the two groups. The FVPTC patients had a more favorable tumor risk by DeGroot classification (P = 0.003) and MACIS (Metastasis, Age, Completeness of excision, Invasiveness, and Size) score (P = 0.026). The 10- and 15-year actuarial disease-specific survivals did not differ significantly between FVPTC and CPTC patients (96.2% versus 90.7% and 96.2% versus 89.1%, respectively). CONCLUSIONS: Although patients with FVPTC had more favorable clinicopathologic features and a better tumor risk group profile, their long-term outcome was similar to that of CPTC patients.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/-
dc.relation.ispartofWorld Journal of Surgery-
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshAdenocarcinoma, Papillary - mortality - pathology - surgery-
dc.subject.meshLymph Node Excision-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshThyroid Neoplasms - mortality - pathology - surgery-
dc.subject.meshThyroidectomy - mortality-
dc.titleClassical and follicular variant of papillary thyroid carcinoma: A comparative study on clinicopathologic features and long-term outcomeen_US
dc.typeArticleen_US
dc.identifier.emailLang, BH: blang@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00268-005-0356-7-
dc.identifier.pmid16680590-
dc.identifier.scopuseid_2-s2.0-33646559829-
dc.identifier.hkuros116465-
dc.identifier.volume30-
dc.identifier.issue5-
dc.identifier.spage752-
dc.identifier.epage758-
dc.identifier.isiWOS:000237398300014-
dc.publisher.placeUnited States-

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