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Article: Restaging of differentiated thyroid carcinoma by the sixth edition AJCC/UICC TNM staging system: Stage migration and predictability

TitleRestaging of differentiated thyroid carcinoma by the sixth edition AJCC/UICC TNM staging system: Stage migration and predictability
Authors
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals of Surgical Oncology, 2007, v. 14 n. 5, p. 1551-1559 How to Cite?
AbstractBACKGROUND: The AJCC/UICC TNM staging system (TNM) is a widely accepted system for differentiated thyroid carcinoma (DTC). The objective of the present study was to evaluate the potential changes in cancer-specific survival (CSS) after reclassification from fifth to sixth edition TNM. METHODS: A total of 760 DTC patients managed at our institution from 1961 to 2001 were retrospectively restaged from the fifth to sixth edition TNM. CSS were calculated using Kaplan-Meier method and were compared by the log-rank test. The relative ability of each edition in predicting CSS was calculated by the proportion of variance explained (PVE). RESULTS: Upon reclassification, the proportion of T1 and T3 tumors increased from 14.2 to 33.4% and 10.0 to 33.7%; T2 and T4 decreased from 44.2 to 25.0% and 31.6 to 7.9%, respectively; N0 remained unchanged at 66.0%; N1a decreased from 25.7 to 4.7%; N1b increased from 8.4 to 29.3%; stages I and IV tumors increased from 55.7 to 60.3% and 3.4 to 17.6%, respectively; stages II and III tumors decreased from 20.5 to 13.9% and 20.4 to 8.2%, respectively. The sixth edition had a higher PVE value than the fifth edition. Significant differences in CSS were observed between stage III (fifth edition) and stage III (sixth edition) and between stage IV (fifth edition) and stage IVA (sixth edition). CONCLUSIONS: The sixth edition TNM caused marked changes in the pT, pN and allocation of patients into different tumor stages. It appeared to have superior predictability over the fifth edition.
Persistent Identifierhttp://hdl.handle.net/10722/192064
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, B-
dc.contributor.authorLo, CY-
dc.contributor.authorChan, WF-
dc.contributor.authorLam, KY-
dc.contributor.authorWan, KY-
dc.date.accessioned2013-10-16T09:36:08Z-
dc.date.available2013-10-16T09:36:08Z-
dc.date.issued2007-
dc.identifier.citationAnnals of Surgical Oncology, 2007, v. 14 n. 5, p. 1551-1559-
dc.identifier.issn1068-9265-
dc.identifier.urihttp://hdl.handle.net/10722/192064-
dc.description.abstractBACKGROUND: The AJCC/UICC TNM staging system (TNM) is a widely accepted system for differentiated thyroid carcinoma (DTC). The objective of the present study was to evaluate the potential changes in cancer-specific survival (CSS) after reclassification from fifth to sixth edition TNM. METHODS: A total of 760 DTC patients managed at our institution from 1961 to 2001 were retrospectively restaged from the fifth to sixth edition TNM. CSS were calculated using Kaplan-Meier method and were compared by the log-rank test. The relative ability of each edition in predicting CSS was calculated by the proportion of variance explained (PVE). RESULTS: Upon reclassification, the proportion of T1 and T3 tumors increased from 14.2 to 33.4% and 10.0 to 33.7%; T2 and T4 decreased from 44.2 to 25.0% and 31.6 to 7.9%, respectively; N0 remained unchanged at 66.0%; N1a decreased from 25.7 to 4.7%; N1b increased from 8.4 to 29.3%; stages I and IV tumors increased from 55.7 to 60.3% and 3.4 to 17.6%, respectively; stages II and III tumors decreased from 20.5 to 13.9% and 20.4 to 8.2%, respectively. The sixth edition had a higher PVE value than the fifth edition. Significant differences in CSS were observed between stage III (fifth edition) and stage III (sixth edition) and between stage IV (fifth edition) and stage IVA (sixth edition). CONCLUSIONS: The sixth edition TNM caused marked changes in the pT, pN and allocation of patients into different tumor stages. It appeared to have superior predictability over the fifth edition.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org-
dc.relation.ispartofAnnals of Surgical Oncology-
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshAdenocarcinoma - pathology - secondary - therapy-
dc.subject.meshAdenocarcinoma, Follicular - pathology - secondary - therapy-
dc.subject.meshCarcinoma, Papillary - pathology - secondary - therapy-
dc.subject.meshNeoplasm Invasiveness - pathology-
dc.subject.meshThyroid Neoplasms - pathology - therapy-
dc.titleRestaging of differentiated thyroid carcinoma by the sixth edition AJCC/UICC TNM staging system: Stage migration and predictabilityen_US
dc.typeArticleen_US
dc.identifier.emailLang, B: blang@hku.hk-
dc.identifier.emailLo, CY: cylo@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/s10434-006-9242-2-
dc.identifier.pmid17318278-
dc.identifier.scopuseid_2-s2.0-34249100947-
dc.identifier.hkuros136167-
dc.identifier.volume14-
dc.identifier.issue5-
dc.identifier.spage1551-
dc.identifier.epage1559-
dc.identifier.isiWOS:000246591200008-
dc.publisher.placeUnited States-

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