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Article: Staging systems for papillary thyroid carcinoma: A study of 2 tertiary referral centers

TitleStaging systems for papillary thyroid carcinoma: A study of 2 tertiary referral centers
Authors
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
Citation
Annals of Surgery, 2007, v. 246 n. 1, p. 114-121 How to Cite?
AbstractOBJECTIVE: To find out the most applicable and consistent staging system for papillary thyroid carcinoma (PTC) available in the literature. BACKGROUND: The commonly used staging systems for PTC have predicted cancer-specific survival (CSS) well. However, their applicability and generalizability have not yet been evaluated in different clinical settings. METHODS: A MEDLINE search from 1965 to 2005 was carried out to identify different staging systems available in the literature and 9 systems were applicable to 1634 PTC patients within 2 tertiary-referral centers. The CSS of each staging system within individual centers were calculated using Kaplan-Meier method and the CSS of each tumor stage in one individual center was compared with that of the other by log-rank test. In addition, within each center, the predictability of each staging system relative to the others was ranked based on the proportion of variation explained (PVE) value. RESULTS: Clinicopathologic features, treatment received, and tumor stages were significantly different between the 2 centers. There were also significant differences in CSS within at least one tumor stage between the 2 centers in 8 of the 9 staging systems. The TNM was a highly predictive and consistent staging system within the 2 centers. Although the absolute PVE values differed between the 2 centers, the relative ranking of the 9 staging systems within each center correlated significantly to each other (P < 0.05). CONCLUSIONS: Despite referral, treatment, and data collection biases inherent within each center, the TNM system remained to be the most applicable and consistent staging system for PTC in 2 centers managing the same population group.
Persistent Identifierhttp://hdl.handle.net/10722/192062
ISSN
2015 Impact Factor: 8.569
2015 SCImago Journal Rankings: 4.503
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, BHH-
dc.contributor.authorChow, SM-
dc.contributor.authorLo, CY-
dc.contributor.authorLaw, SCK-
dc.contributor.authorLam, KY-
dc.date.accessioned2013-10-16T09:27:18Z-
dc.date.available2013-10-16T09:27:18Z-
dc.date.issued2007-
dc.identifier.citationAnnals of Surgery, 2007, v. 246 n. 1, p. 114-121-
dc.identifier.issn0003-4932-
dc.identifier.urihttp://hdl.handle.net/10722/192062-
dc.description.abstractOBJECTIVE: To find out the most applicable and consistent staging system for papillary thyroid carcinoma (PTC) available in the literature. BACKGROUND: The commonly used staging systems for PTC have predicted cancer-specific survival (CSS) well. However, their applicability and generalizability have not yet been evaluated in different clinical settings. METHODS: A MEDLINE search from 1965 to 2005 was carried out to identify different staging systems available in the literature and 9 systems were applicable to 1634 PTC patients within 2 tertiary-referral centers. The CSS of each staging system within individual centers were calculated using Kaplan-Meier method and the CSS of each tumor stage in one individual center was compared with that of the other by log-rank test. In addition, within each center, the predictability of each staging system relative to the others was ranked based on the proportion of variation explained (PVE) value. RESULTS: Clinicopathologic features, treatment received, and tumor stages were significantly different between the 2 centers. There were also significant differences in CSS within at least one tumor stage between the 2 centers in 8 of the 9 staging systems. The TNM was a highly predictive and consistent staging system within the 2 centers. Although the absolute PVE values differed between the 2 centers, the relative ranking of the 9 staging systems within each center correlated significantly to each other (P < 0.05). CONCLUSIONS: Despite referral, treatment, and data collection biases inherent within each center, the TNM system remained to be the most applicable and consistent staging system for PTC in 2 centers managing the same population group.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com-
dc.relation.ispartofAnnals of Surgery-
dc.rightsThis is a non-final version of an article published in final form in Annals of Surgery, 2007, v. 246 n. 1, p. 114-121-
dc.subject.meshCarcinoma, Papillary - mortality - pathology-
dc.subject.meshNeoplasm Staging - instrumentation-
dc.subject.meshReferral and Consultation-
dc.subject.meshReproducibility of Results-
dc.subject.meshThyroid Neoplasms - mortality - pathology-
dc.titleStaging systems for papillary thyroid carcinoma: A study of 2 tertiary referral centersen_US
dc.typeArticleen_US
dc.identifier.emailLang, BHH: blang@HKUCC.hku.hk-
dc.identifier.emailLo, CY: cylo@hkucc.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.sla.0000262785.46403.9b-
dc.identifier.pmid17592299-
dc.identifier.pmcidPMC1899202-
dc.identifier.scopuseid_2-s2.0-34347335723-
dc.identifier.hkuros133464-
dc.identifier.volume246-
dc.identifier.issue1-
dc.identifier.spage114-
dc.identifier.epage121-
dc.identifier.isiWOS:000247672300018-
dc.publisher.placeUnited States-

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