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Article: Analyzing the genomic variation of microbial cell factories in the era of “New Biotechnology”

TitleAnalyzing the genomic variation of microbial cell factories in the era of “New Biotechnology”
Authors
Issue Date2012
PublisherResearch Network of Computational and Structural Biotechnology. The Journal's web site is located at http://journals.sfu.ca/rncsb/index.php/csbj
Citation
Computational and Structural Biotechnology Journal, 2012, v. 3 n. 4, p. e201210012 How to Cite?
AbstractThe application of genome-scale technologies, both experimental and in silico, to industrial biotechnology has allowed improving the conversion of biomass-derived feedstocks to chemicals, materials and fuels through microbial fermentation. In particular, due to rapidly decreasing costs and its suitability for identifying the genetic determinants of a phenotypic trait of interest, whole genome sequencing is expected to be one of the major driving forces in industrial biotechnology in the coming years. We present some of the recent studies that have successfully applied high-throughput sequencing technologies for finding the underlying molecular mechanisms for (a) improved carbon source utilization, (b) increased product formation, and (c) stress tolerance. We also discuss the strengths and weaknesses of different strategies for mapping industrially relevant genotype-to-phenotype links including exploiting natural diversity in natural isolates or crosses between isolates, classical mutagenesis and evolutionary engineering.
Persistent Identifierhttp://hdl.handle.net/10722/191795
ISSN
2015 SCImago Journal Rankings: 0.753

 

DC FieldValueLanguage
dc.contributor.authorHerrgård, Men_US
dc.contributor.authorPanagiotou, Gen_US
dc.date.accessioned2013-10-15T07:24:34Z-
dc.date.available2013-10-15T07:24:34Z-
dc.date.issued2012en_US
dc.identifier.citationComputational and Structural Biotechnology Journal, 2012, v. 3 n. 4, p. e201210012en_US
dc.identifier.issn2001-0370en_US
dc.identifier.urihttp://hdl.handle.net/10722/191795-
dc.description.abstractThe application of genome-scale technologies, both experimental and in silico, to industrial biotechnology has allowed improving the conversion of biomass-derived feedstocks to chemicals, materials and fuels through microbial fermentation. In particular, due to rapidly decreasing costs and its suitability for identifying the genetic determinants of a phenotypic trait of interest, whole genome sequencing is expected to be one of the major driving forces in industrial biotechnology in the coming years. We present some of the recent studies that have successfully applied high-throughput sequencing technologies for finding the underlying molecular mechanisms for (a) improved carbon source utilization, (b) increased product formation, and (c) stress tolerance. We also discuss the strengths and weaknesses of different strategies for mapping industrially relevant genotype-to-phenotype links including exploiting natural diversity in natural isolates or crosses between isolates, classical mutagenesis and evolutionary engineering.en_US
dc.languageengen_US
dc.publisherResearch Network of Computational and Structural Biotechnology. The Journal's web site is located at http://journals.sfu.ca/rncsb/index.php/csbjen_US
dc.relation.ispartofComputational and Structural Biotechnology Journalen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.titleAnalyzing the genomic variation of microbial cell factories in the era of “New Biotechnology”en_US
dc.typeArticleen_US
dc.identifier.emailPanagiotou, G: gipa@hku.hken_US
dc.identifier.authorityPanagiotou, G=rp01725en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5936/csbj.201210012en_US
dc.identifier.hkuros221464en_US
dc.identifier.volume3en_US
dc.identifier.issue4en_US
dc.identifier.spagee201210012en_US
dc.identifier.epagee201210012en_US
dc.publisher.placeDenmarken_US

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