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Conference Paper: In vivo assessments of ocular dynamics, axonal transport and microstructural integrity in the visual system upon neonatal hypoxic-ischemic injury

TitleIn vivo assessments of ocular dynamics, axonal transport and microstructural integrity in the visual system upon neonatal hypoxic-ischemic injury
Authors
Issue Date2013
PublisherISMRM.
Citation
The 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 0336 How to Cite?
AbstractThis study employed dynamic gadolinium-enhanced MRI, manganese-enhanced MRI and diffusion tensor imaging to evaluate the ocular dynamics, axonal transport and microstructural integrity in the visual system of adult rats that underwent neonatal unilateral hypoxic-ischemic injury. Dynamic Gd-enhanced MRI showed leakage of the Gd contrast into the vitreous humor from the anterior chamber in the ipsilesional eye but not the contralesional eye after systemic administration of Gd. Manganese-enhanced MRI showed reduced anterograde axonal transport of Mn2+ ions along the visual pathway projected from the ipsilesional eye compared to contralesional eye upon bilateral Mn2+ intravitreal injection. In addition, the superior colliculus ipsilateral to the injured hemisphere appeared to be displaced across the midline to the contralateral hemisphere. Diffusion tensor imaging showed disorganization of the ipsilesional optic nerve compared to the contralesional optic nerve. The results of this study provided important evidence for understanding the chronic pathophysiological changes in the visual system after neonatal unilateral hypoxic-ischemic injury. (Abstract by ISMRM)
DescriptionScientific Session - Animal Models 2
Persistent Identifierhttp://hdl.handle.net/10722/191636
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_US
dc.contributor.authorKancherla, Sen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2013-10-15T07:14:47Z-
dc.date.available2013-10-15T07:14:47Z-
dc.date.issued2013en_US
dc.identifier.citationThe 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 0336en_US
dc.identifier.issn1557-3672-
dc.identifier.urihttp://hdl.handle.net/10722/191636-
dc.descriptionScientific Session - Animal Models 2-
dc.description.abstractThis study employed dynamic gadolinium-enhanced MRI, manganese-enhanced MRI and diffusion tensor imaging to evaluate the ocular dynamics, axonal transport and microstructural integrity in the visual system of adult rats that underwent neonatal unilateral hypoxic-ischemic injury. Dynamic Gd-enhanced MRI showed leakage of the Gd contrast into the vitreous humor from the anterior chamber in the ipsilesional eye but not the contralesional eye after systemic administration of Gd. Manganese-enhanced MRI showed reduced anterograde axonal transport of Mn2+ ions along the visual pathway projected from the ipsilesional eye compared to contralesional eye upon bilateral Mn2+ intravitreal injection. In addition, the superior colliculus ipsilateral to the injured hemisphere appeared to be displaced across the midline to the contralateral hemisphere. Diffusion tensor imaging showed disorganization of the ipsilesional optic nerve compared to the contralesional optic nerve. The results of this study provided important evidence for understanding the chronic pathophysiological changes in the visual system after neonatal unilateral hypoxic-ischemic injury. (Abstract by ISMRM)-
dc.languageengen_US
dc.publisherISMRM.-
dc.relation.ispartofSociety of Magnetic Resonance in Medicine Proceedingsen_US
dc.titleIn vivo assessments of ocular dynamics, axonal transport and microstructural integrity in the visual system upon neonatal hypoxic-ischemic injuryen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros225993en_US
dc.identifier.volume21-
dc.identifier.spage0336en_US
dc.identifier.epage0336en_US
dc.publisher.placeUnited Statesen_US

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