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Conference Paper: Assessment of degradation of proteoglycans and matrix proteins in intervertebral disc degeneration by diffusion weighted MRS
Title | Assessment of degradation of proteoglycans and matrix proteins in intervertebral disc degeneration by diffusion weighted MRS |
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Authors | |
Issue Date | 2013 |
Publisher | International Society for Magnetic Resonance in Medicine (ISMRM). |
Citation | The 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 0432 How to Cite? |
Abstract | This study investigated the capability of diffusion weighted magnetic resonance spectroscopy (DW-MRS) for assessing the changes in carbohydrates region (3.5-4.2ppm) during intervertebral disc degeneration (IVDD). Our experimental results demonstrated that spectral contamination of carbohydrate resonances by overlapping water peak could be effectively suppressed by diffusion weighting due to the fast water diffusion (compared to macromolecules). More importantly, we demonstrated that non-water diffusion measurement could detect proteoglycan and disc matrix protein breakdowns during disc degeneration. Such diffusion spectroscopy approval can constitute a new and useful tool for early IVDD detection and mechanistic understanding of IVDD. (Abstract by ISMRM) |
Description | Scientific Session - Cartilage & Basic Science: Emerging Techniques ISMRM Merit Award: Magna cum Laude |
Persistent Identifier | http://hdl.handle.net/10722/191628 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Wang, AM | en_US |
dc.contributor.author | Cao, P | en_US |
dc.contributor.author | Yang, J | en_US |
dc.contributor.author | Wu, EX | en_US |
dc.date.accessioned | 2013-10-15T07:14:44Z | - |
dc.date.available | 2013-10-15T07:14:44Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 0432 | en_US |
dc.identifier.issn | 1557-3672 | - |
dc.identifier.uri | http://hdl.handle.net/10722/191628 | - |
dc.description | Scientific Session - Cartilage & Basic Science: Emerging Techniques | - |
dc.description | ISMRM Merit Award: Magna cum Laude | - |
dc.description.abstract | This study investigated the capability of diffusion weighted magnetic resonance spectroscopy (DW-MRS) for assessing the changes in carbohydrates region (3.5-4.2ppm) during intervertebral disc degeneration (IVDD). Our experimental results demonstrated that spectral contamination of carbohydrate resonances by overlapping water peak could be effectively suppressed by diffusion weighting due to the fast water diffusion (compared to macromolecules). More importantly, we demonstrated that non-water diffusion measurement could detect proteoglycan and disc matrix protein breakdowns during disc degeneration. Such diffusion spectroscopy approval can constitute a new and useful tool for early IVDD detection and mechanistic understanding of IVDD. (Abstract by ISMRM) | - |
dc.language | eng | en_US |
dc.publisher | International Society for Magnetic Resonance in Medicine (ISMRM). | - |
dc.relation.ispartof | Society of Magnetic Resonance in Medicine Proceedings | en_US |
dc.title | Assessment of degradation of proteoglycans and matrix proteins in intervertebral disc degeneration by diffusion weighted MRS | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wu, EX: ewu1@hkucc.hku.hk | en_US |
dc.identifier.authority | Wu, EX=rp00193 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 225970 | en_US |
dc.identifier.volume | 21 | - |
dc.identifier.spage | 0432 | - |
dc.identifier.epage | 0432 | - |
dc.publisher.place | United States | en_US |
dc.identifier.issnl | 1065-9889 | - |