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Conference Paper: Assessment of degradation of proteoglycans and matrix proteins in intervertebral disc degeneration by diffusion weighted MRS

TitleAssessment of degradation of proteoglycans and matrix proteins in intervertebral disc degeneration by diffusion weighted MRS
Authors
Issue Date2013
PublisherInternational Society for Magnetic Resonance in Medicine (ISMRM).
Citation
The 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 0432 How to Cite?
AbstractThis study investigated the capability of diffusion weighted magnetic resonance spectroscopy (DW-MRS) for assessing the changes in carbohydrates region (3.5-4.2ppm) during intervertebral disc degeneration (IVDD). Our experimental results demonstrated that spectral contamination of carbohydrate resonances by overlapping water peak could be effectively suppressed by diffusion weighting due to the fast water diffusion (compared to macromolecules). More importantly, we demonstrated that non-water diffusion measurement could detect proteoglycan and disc matrix protein breakdowns during disc degeneration. Such diffusion spectroscopy approval can constitute a new and useful tool for early IVDD detection and mechanistic understanding of IVDD. (Abstract by ISMRM)
DescriptionScientific Session - Cartilage & Basic Science: Emerging Techniques
ISMRM Merit Award: Magna cum Laude
Persistent Identifierhttp://hdl.handle.net/10722/191628
ISSN

 

DC FieldValueLanguage
dc.contributor.authorWang, AMen_US
dc.contributor.authorCao, Pen_US
dc.contributor.authorYang, Jen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2013-10-15T07:14:44Z-
dc.date.available2013-10-15T07:14:44Z-
dc.date.issued2013en_US
dc.identifier.citationThe 21st Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT., 20-26 April 2013. In Society of Magnetic Resonance in Medicine Proceedings, 2013, v. 21, p. 0432en_US
dc.identifier.issn1557-3672-
dc.identifier.urihttp://hdl.handle.net/10722/191628-
dc.descriptionScientific Session - Cartilage & Basic Science: Emerging Techniques-
dc.descriptionISMRM Merit Award: Magna cum Laude-
dc.description.abstractThis study investigated the capability of diffusion weighted magnetic resonance spectroscopy (DW-MRS) for assessing the changes in carbohydrates region (3.5-4.2ppm) during intervertebral disc degeneration (IVDD). Our experimental results demonstrated that spectral contamination of carbohydrate resonances by overlapping water peak could be effectively suppressed by diffusion weighting due to the fast water diffusion (compared to macromolecules). More importantly, we demonstrated that non-water diffusion measurement could detect proteoglycan and disc matrix protein breakdowns during disc degeneration. Such diffusion spectroscopy approval can constitute a new and useful tool for early IVDD detection and mechanistic understanding of IVDD. (Abstract by ISMRM)-
dc.languageengen_US
dc.publisherInternational Society for Magnetic Resonance in Medicine (ISMRM).-
dc.relation.ispartofSociety of Magnetic Resonance in Medicine Proceedingsen_US
dc.titleAssessment of degradation of proteoglycans and matrix proteins in intervertebral disc degeneration by diffusion weighted MRSen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros225970en_US
dc.identifier.volume21-
dc.identifier.spage0432-
dc.identifier.epage0432-
dc.publisher.placeUnited Statesen_US

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