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Conference Paper: Diffusion kurtosis imaging with tract-based spatial statistics reveals white matter alterations in preschool children

TitleDiffusion kurtosis imaging with tract-based spatial statistics reveals white matter alterations in preschool children
Authors
Issue Date2012
PublisherInstitute of Electrical and Electronics Engineers. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2012), San Diego, CA., 28 August-1 September 2012. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2012, p. 2298-2301 How to Cite?
AbstractDiffusion kurtosis imaging (DKI), an extension of diffusion tensor imaging (DTI), provides a practical method to describe non-Gaussian water diffusion in neural tissues. The sensitivity of DKI to detect the subtle changes in several chosen brain structures has been studied. However, intuitive and holistic methods to validate the merits of DKI remain to be explored. In this paper, tract-based spatial statistics (TBSS) was used to demonstrate white matter alterations in both DKI and DTI parameters in preschool children (1-6 years; n=10). Correlation analysis was also performed in multiple regions of interest (ROIs). Fractional anisotropy, mean kurtosis, axial kurtosis and radial kurtosis increased with age, while mean diffusivity and radial diffusivity decreased significantly with age. Fractional anisotropy of kurtosis and axial diffusivity were found to be less sensitive to the changes with age. These preliminary findings indicated that TBSS could be used to detect subtle changes of DKI parameters on the white matter tract. Kurtosis parameters, except fractional anisotropy of kurtosis, demonstrated higher sensitivity than DTI parameters. TBSS may be a convenient method to yield higher sensitivity of DKI.
Persistent Identifierhttp://hdl.handle.net/10722/191625
ISBN
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_US
dc.contributor.authorGao, Jen_US
dc.contributor.authorHou, Xen_US
dc.contributor.authorChan, KCen_US
dc.contributor.authorDing, Aen_US
dc.contributor.authorSun, Qen_US
dc.contributor.authorWan, Men_US
dc.contributor.authorWu, EXen_US
dc.contributor.authorYang, J-
dc.date.accessioned2013-10-15T07:14:43Z-
dc.date.available2013-10-15T07:14:43Z-
dc.date.issued2012en_US
dc.identifier.citationThe 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2012), San Diego, CA., 28 August-1 September 2012. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2012, p. 2298-2301en_US
dc.identifier.isbn978-1-4577-1787-1-
dc.identifier.issn1557-170X-
dc.identifier.urihttp://hdl.handle.net/10722/191625-
dc.description.abstractDiffusion kurtosis imaging (DKI), an extension of diffusion tensor imaging (DTI), provides a practical method to describe non-Gaussian water diffusion in neural tissues. The sensitivity of DKI to detect the subtle changes in several chosen brain structures has been studied. However, intuitive and holistic methods to validate the merits of DKI remain to be explored. In this paper, tract-based spatial statistics (TBSS) was used to demonstrate white matter alterations in both DKI and DTI parameters in preschool children (1-6 years; n=10). Correlation analysis was also performed in multiple regions of interest (ROIs). Fractional anisotropy, mean kurtosis, axial kurtosis and radial kurtosis increased with age, while mean diffusivity and radial diffusivity decreased significantly with age. Fractional anisotropy of kurtosis and axial diffusivity were found to be less sensitive to the changes with age. These preliminary findings indicated that TBSS could be used to detect subtle changes of DKI parameters on the white matter tract. Kurtosis parameters, except fractional anisotropy of kurtosis, demonstrated higher sensitivity than DTI parameters. TBSS may be a convenient method to yield higher sensitivity of DKI.-
dc.languageengen_US
dc.publisherInstitute of Electrical and Electronics Engineers. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofIEEE Engineering in Medicine and Biology Society Conference Proceedingsen_US
dc.rightsIEEE Engineering in Medicine and Biology Society Conference Proceedings. Copyright © Institute of Electrical and Electronics Engineers.-
dc.rights©2012 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAlgorithms-
dc.subject.meshBrain - cytology-
dc.subject.meshDiffusion Tensor Imaging - methods-
dc.subject.meshImage Interpretation, Computer-Assisted - methods-
dc.subject.meshImaging, Three-Dimensional - methods-
dc.subject.meshNerve Fibers, Myelinated - ultrastructure-
dc.titleDiffusion kurtosis imaging with tract-based spatial statistics reveals white matter alterations in preschool childrenen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1109/EMBC.2012.6346422-
dc.identifier.pmid23366383-
dc.identifier.scopuseid_2-s2.0-84870843973-
dc.identifier.hkuros225954en_US
dc.identifier.hkuros225965-
dc.identifier.spage2298-
dc.identifier.epage2301-
dc.publisher.placeUnited Statesen_US
dc.customcontrol.immutablesml 131107-

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