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Conference Paper: In vivo manganese-enhanced MRI for visuotopic brain mapping

TitleIn vivo manganese-enhanced MRI for visuotopic brain mapping
Authors
KeywordsVisual Perception - physiology
Issue Date2012
PublisherInstitute of Electrical and Electronics Engineers. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2012), San Diego, CA., 28 August-1 September 2012. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2012, p. 2279-2282 How to Cite?
AbstractThis study explored the feasibility of localized manganese-enhanced MRI (MEMRI) via 3 different routes of Mn(2+) administrations for visuotopic brain mapping of retinal, callosal, cortico-subcortical, transsynaptic and horizontal connections in normal adult rats. Upon fractionated intravitreal Mn(2+) injection, Mn enhancements were observed in the contralateral superior colliculus (SC) and lateral geniculate nucleus (LGN) by 45-60% at 1-3 days after initial Mn(2+) injection and in the contralateral primary visual cortex (V1) by about 10% at 2-3 days after initial Mn(2+) injection. Direct, single-dose Mn(2+) injection to the LGN resulted in Mn enhancement by 13-21% in V1 and 8-11% in SC of the ipsilateral hemisphere at 8 to 24 hours after Mn(2+) administration. Intracortical, single-dose Mn(2+) injection to the visual cortex resulted in Mn enhancement by 53-65% in ipsilateral LGN, 15-26% in ipsilateral SC, 32-34% in the splenium of corpus callosum and 17-25% in contralateral V1/V2 transition zone at 8 to 24 hours after Mn(2+) administration. Notably, some patchy patterns were apparent near the V1/V2 border of the contralateral hemisphere. Laminar-specific horizontal cortical connections were also observed in the ipsilateral hemisphere. The current results demonstrated the sensitivity of MEMRI for assessing the neuroarchitecture of the visual brains in vivo without depth-limitation, and may possess great potentials for studying the basic neural components and connections in the visual system longitudinally during development, plasticity, pharmacological interventions and genetic modifications.
Persistent Identifierhttp://hdl.handle.net/10722/191623
ISBN
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2013-10-15T07:14:43Z-
dc.date.available2013-10-15T07:14:43Z-
dc.date.issued2012en_US
dc.identifier.citationThe 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2012), San Diego, CA., 28 August-1 September 2012. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2012, p. 2279-2282en_US
dc.identifier.isbn978-1-4577-1787-1-
dc.identifier.issn1557-170X-
dc.identifier.urihttp://hdl.handle.net/10722/191623-
dc.description.abstractThis study explored the feasibility of localized manganese-enhanced MRI (MEMRI) via 3 different routes of Mn(2+) administrations for visuotopic brain mapping of retinal, callosal, cortico-subcortical, transsynaptic and horizontal connections in normal adult rats. Upon fractionated intravitreal Mn(2+) injection, Mn enhancements were observed in the contralateral superior colliculus (SC) and lateral geniculate nucleus (LGN) by 45-60% at 1-3 days after initial Mn(2+) injection and in the contralateral primary visual cortex (V1) by about 10% at 2-3 days after initial Mn(2+) injection. Direct, single-dose Mn(2+) injection to the LGN resulted in Mn enhancement by 13-21% in V1 and 8-11% in SC of the ipsilateral hemisphere at 8 to 24 hours after Mn(2+) administration. Intracortical, single-dose Mn(2+) injection to the visual cortex resulted in Mn enhancement by 53-65% in ipsilateral LGN, 15-26% in ipsilateral SC, 32-34% in the splenium of corpus callosum and 17-25% in contralateral V1/V2 transition zone at 8 to 24 hours after Mn(2+) administration. Notably, some patchy patterns were apparent near the V1/V2 border of the contralateral hemisphere. Laminar-specific horizontal cortical connections were also observed in the ipsilateral hemisphere. The current results demonstrated the sensitivity of MEMRI for assessing the neuroarchitecture of the visual brains in vivo without depth-limitation, and may possess great potentials for studying the basic neural components and connections in the visual system longitudinally during development, plasticity, pharmacological interventions and genetic modifications.-
dc.languageengen_US
dc.publisherInstitute of Electrical and Electronics Engineers. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofIEEE Engineering in Medicine and Biology Society Conference Proceedingsen_US
dc.rightsIEEE Engineering in Medicine and Biology Society Conference Proceedings. Copyright © Institute of Electrical and Electronics Engineers.-
dc.rights©2012 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectVisual Perception - physiology-
dc.subject.meshBrain Mapping - methods-
dc.subject.meshEvoked Potentials, Visual - physiology-
dc.subject.meshImage Enhancement - methods-
dc.subject.meshMagnetic Resonance Imaging - methods-
dc.subject.meshManganese - diagnostic use-
dc.subject.meshNerve Net - physiology-
dc.titleIn vivo manganese-enhanced MRI for visuotopic brain mappingen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX: ewu@eee.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1109/EMBC.2012.6346417-
dc.identifier.pmid23366378-
dc.identifier.scopuseid_2-s2.0-84870840390-
dc.identifier.hkuros225949en_US
dc.identifier.spage2279-
dc.identifier.epage2282-
dc.publisher.placeUnited Statesen_US
dc.customcontrol.immutablesml 131107-

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