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Article: Use of liver stiffness measurement for liver resection surgery: correlation with indocyanine green clearance testing and post-operative outcome

TitleUse of liver stiffness measurement for liver resection surgery: correlation with indocyanine green clearance testing and post-operative outcome
Authors
Issue Date2013
Citation
PLoS One, 2013, v. 8 n. 8, p. e72306 How to Cite?
AbstractBackground:Liver stiffness measurement (LSM) using transient elastography has recently become available for the assessment of liver fibrosis. Whether LSM can predict the functional liver reserve in patients undergoing liver resection is not certain.Aim:To correlate liver stiffness measurement (LSM) with indocyanine green (ICG) clearance test and liver biochemistry, and to determine its usefulness in predicting postoperative outcomes in patients undergoing liver resection.Patients and Methods:Transient elastography and ICG clearance test were performed pre-operatively in 44 patients with hepatocellular carcinoma. The LSM and ICG retention rate at 15 minutes (R15) were correlated with pre-operative factors and post-operative outcomes.Results:There was significant correlation between ICG R15 and LSM. In patients with LSM ≥11 kPa vs <11 kPa, there was significantly higher ICG R15 (17.1% vs 10.0% respectively, p = 0.025). For patients with ICG R15≥10% compared to those <10%, there was significantly higher LSM (12.0 vs 7.6 kPa respectively, p = 0.015). Twenty-eight patients proceeded to resection. There was a significant correlation between LSM and the peak INR after liver resection (r = 0.426, p = 0.024). There was a significant correlation between ICG R15 and the post-operative peak AST level (r = -0.414, p = 0.029) and peak ALT level (r = -0.568, p = 0.002). The operative time was a significant independent factor associated with post-operative complications and peak INR.Conclusion:LSM correlated well with ICG R15 in patients undergoing liver resection, and predicted early post-operative complications. Addition of LSM to ICG R15 testing may provide better prognostic information for patients undergoing resection. © 2013 Fung et al.
Persistent Identifierhttp://hdl.handle.net/10722/191415
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFung, JYYen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorYu, WCen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorChan, ACYen_US
dc.contributor.authorChok, KSHen_US
dc.contributor.authorCheung, TTen_US
dc.contributor.authorSeto, WKWen_US
dc.contributor.authorLo, CMen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorYuen, RMFen_US
dc.date.accessioned2013-10-15T06:58:23Z-
dc.date.available2013-10-15T06:58:23Z-
dc.date.issued2013en_US
dc.identifier.citationPLoS One, 2013, v. 8 n. 8, p. e72306en_US
dc.identifier.urihttp://hdl.handle.net/10722/191415-
dc.description.abstractBackground:Liver stiffness measurement (LSM) using transient elastography has recently become available for the assessment of liver fibrosis. Whether LSM can predict the functional liver reserve in patients undergoing liver resection is not certain.Aim:To correlate liver stiffness measurement (LSM) with indocyanine green (ICG) clearance test and liver biochemistry, and to determine its usefulness in predicting postoperative outcomes in patients undergoing liver resection.Patients and Methods:Transient elastography and ICG clearance test were performed pre-operatively in 44 patients with hepatocellular carcinoma. The LSM and ICG retention rate at 15 minutes (R15) were correlated with pre-operative factors and post-operative outcomes.Results:There was significant correlation between ICG R15 and LSM. In patients with LSM ≥11 kPa vs <11 kPa, there was significantly higher ICG R15 (17.1% vs 10.0% respectively, p = 0.025). For patients with ICG R15≥10% compared to those <10%, there was significantly higher LSM (12.0 vs 7.6 kPa respectively, p = 0.015). Twenty-eight patients proceeded to resection. There was a significant correlation between LSM and the peak INR after liver resection (r = 0.426, p = 0.024). There was a significant correlation between ICG R15 and the post-operative peak AST level (r = -0.414, p = 0.029) and peak ALT level (r = -0.568, p = 0.002). The operative time was a significant independent factor associated with post-operative complications and peak INR.Conclusion:LSM correlated well with ICG R15 in patients undergoing liver resection, and predicted early post-operative complications. Addition of LSM to ICG R15 testing may provide better prognostic information for patients undergoing resection. © 2013 Fung et al.-
dc.languageengen_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleUse of liver stiffness measurement for liver resection surgery: correlation with indocyanine green clearance testing and post-operative outcomeen_US
dc.typeArticleen_US
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hku.hken_US
dc.identifier.emailYu, WC: yuwc@hku.hken_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailChan, ACY: acchan@hku.hken_US
dc.identifier.emailCheung, TT: cheung68@hku.hken_US
dc.identifier.emailSeto, WKW: wkseto2@hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.emailLai, CL: hrmelcl@hku.hken_US
dc.identifier.emailYuen, RMF: mfyuen@hku.hken_US
dc.identifier.authorityFung, JYY=rp00518en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.authorityChan, SC=rp01568en_US
dc.identifier.authorityChan, ACY=rp00310en_US
dc.identifier.authoritySeto, WKW=rp01659en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.identifier.authorityYuen, RMF=rp00479en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0072306-
dc.identifier.pmid24015232-
dc.identifier.scopuseid_2-s2.0-84883168051-
dc.identifier.hkuros225774en_US
dc.identifier.volume8en_US
dc.identifier.issue8en_US
dc.identifier.spagee72306en_US
dc.identifier.epagee72306en_US
dc.identifier.isiWOS:000323733800045-

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