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Article: Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents

TitleSecular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents
Authors
Issue Date2013
Citation
BMC Cancer, 2013, v. 13 n. 1, p. 298 How to Cite?
AbstractBackground: Despite salted fish being a classical risk factor of Nasopharyngeal Carcinoma (NPC), whether secular trends in salted fish consumption worldwide accounted for changes in NPC rates were unknown. The relationship between vegetable and cigarette consumption to NPC risk worldwide were also largely uncertain. We investigated the longitudinal trends in standardised NPC incidence/mortality rates across 8 regions and their associations with secular trends in salted fish, vegetable and tobacco consumptions. Methods: Age standardised mortality rate (ASMR) and age standardised incidence rate (ASIR) of NPC were obtained from the WHO cancer mortality database and Hong Kong Cancer Registry. Per capita consumption of salted fish, tobacco and vegetables in Hong Kong and 7 countries (China, Finland, Japan, Portugal, Singapore, United Kingdom and United States) were obtained from the Food and Agriculture Organization of the United Nation (FAO) and Hong Kong Trade and Census Statistics. Pearson correlation and multivariate analysis were performed to examine both crude and adjusted associations. Results: There were markedly decreasing trends of NPC ASIR and ASMR in Hong Kong over the past three decades, which were correlated with corresponding secular changes in salted fish consumption per capita (Pearson r for 10 cumulative years : ASIR = 0.729 (male), 0.674 (female); ASMR = 0.943 (male), 0.622 (female), all p < 0.05 except for female ASMR). However such associations no longer correlated with adjustments for decreasing tobacco and increasing vegetable consumption per capita (Pearson r for 10 cumulative years: ASIR = 2.007 (male), 0.339 (female), ASMR = 0.289 (male), 1.992 (female), all p > 0.05). However, there were no clear or consistent patterns in relations between NPC ASIR and ASMR with salted fish consumption across 7 regions in 3 continents. Conclusions: Our results do not support the notion that changes in salted fish consumption had played an important role in explaining secular trends of NPC rates in Hong Kong and worldwide. Further studies should explore other lifestyle and genetic factors. However, our findings do support the potentially protective effects of vegetable consumption against NPC.
Persistent Identifierhttp://hdl.handle.net/10722/191035
ISSN
2015 Impact Factor: 3.265
2015 SCImago Journal Rankings: 1.627
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLAU, HYen_US
dc.contributor.authorLeung, CMen_US
dc.contributor.authorChan, YHen_US
dc.contributor.authorLee, AWMen_US
dc.contributor.authorKwong, DLWen_US
dc.contributor.authorLung, MLen_US
dc.contributor.authorLam, THen_US
dc.date.accessioned2013-09-17T16:11:48Z-
dc.date.available2013-09-17T16:11:48Z-
dc.date.issued2013en_US
dc.identifier.citationBMC Cancer, 2013, v. 13 n. 1, p. 298en_US
dc.identifier.issn1471-2407-
dc.identifier.urihttp://hdl.handle.net/10722/191035-
dc.description.abstractBackground: Despite salted fish being a classical risk factor of Nasopharyngeal Carcinoma (NPC), whether secular trends in salted fish consumption worldwide accounted for changes in NPC rates were unknown. The relationship between vegetable and cigarette consumption to NPC risk worldwide were also largely uncertain. We investigated the longitudinal trends in standardised NPC incidence/mortality rates across 8 regions and their associations with secular trends in salted fish, vegetable and tobacco consumptions. Methods: Age standardised mortality rate (ASMR) and age standardised incidence rate (ASIR) of NPC were obtained from the WHO cancer mortality database and Hong Kong Cancer Registry. Per capita consumption of salted fish, tobacco and vegetables in Hong Kong and 7 countries (China, Finland, Japan, Portugal, Singapore, United Kingdom and United States) were obtained from the Food and Agriculture Organization of the United Nation (FAO) and Hong Kong Trade and Census Statistics. Pearson correlation and multivariate analysis were performed to examine both crude and adjusted associations. Results: There were markedly decreasing trends of NPC ASIR and ASMR in Hong Kong over the past three decades, which were correlated with corresponding secular changes in salted fish consumption per capita (Pearson r for 10 cumulative years : ASIR = 0.729 (male), 0.674 (female); ASMR = 0.943 (male), 0.622 (female), all p < 0.05 except for female ASMR). However such associations no longer correlated with adjustments for decreasing tobacco and increasing vegetable consumption per capita (Pearson r for 10 cumulative years: ASIR = 2.007 (male), 0.339 (female), ASMR = 0.289 (male), 1.992 (female), all p > 0.05). However, there were no clear or consistent patterns in relations between NPC ASIR and ASMR with salted fish consumption across 7 regions in 3 continents. Conclusions: Our results do not support the notion that changes in salted fish consumption had played an important role in explaining secular trends of NPC rates in Hong Kong and worldwide. Further studies should explore other lifestyle and genetic factors. However, our findings do support the potentially protective effects of vegetable consumption against NPC.-
dc.languageengen_US
dc.relation.ispartofBMC Canceren_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSecular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continentsen_US
dc.typeArticleen_US
dc.identifier.emailChan, YH: chanwill@hku.hken_US
dc.identifier.emailLee, AWM: awmlee@hkucc.hku.hken_US
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_US
dc.identifier.emailLung, ML: mlilung@hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.authorityChan, YH=rp01313en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2407-13-298-
dc.identifier.pmid23782497-
dc.identifier.pmcidPMC3729410-
dc.identifier.scopuseid_2-s2.0-84879066167-
dc.identifier.hkuros224702en_US
dc.identifier.hkuros219563-
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.spage298en_US
dc.identifier.epage298en_US
dc.identifier.isiWOS:000322509600001-

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